Hub : Genes

ZNF618

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.150 0.056 5.2e-03 0.045 NA -0.005 NA 0.012 1.7e-03 NA 9.5e-01 NA 0.06800
2 GTEx Brain Cerebellar Hemisphere 0.479 0.121 1.6e-03 0.235 NA 0.168 NA 0.110 1.0e-06 NA 4.4e-05 NA 0.00092
3 GTEx Brain Cerebellum 0.387 0.096 9.2e-05 0.259 NA 0.222 NA -0.006 2.8e-08 NA 3.5e-07 NA 0.53000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.4 1.0 -0.2 0.5 1.0
Bipolar Disorder or Schizophrenia 0.1 0.1 0.3 0.1 0.3 0.5
Depressed Affect (Nagel 2018) 0.3 0.7 1.6 -0.6 -0.4 -1.3
Depression (Nagel 2018) 0.8 1.2 1.8 1.0 -0.9 -1.4
Intelligence (Savage-Jansen 2018) 0.0 0.2 0.3 -0.2 -0.6 -0.2
Neuroticism (Nagel 2018) 0.2 0.5 1.1 -0.5 -0.2 -1.1
Schizophrenia (2018) 0.0 0.0 0.1 0.3 -0.0 -0.2
Schizophrenia vs Biploar Disorder 0.8 1.0 1.9 -0.0 -1.1 -1.4
Worry (Nagel 2018) 0.1 0.3 0.8 -0.9 0.2 -0.3
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 -0.1 -0.2 -0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.5 -0.2 -0.1
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 -0.0 -0.4 -0.0
Crohns Disease (2017) 1.3 2.9 5.6 0.2 -2.4 -1.7
Irritable Bowel Disease (IBD) 0.3 0.8 2.2 1.5 -0.3 0.1
Ulcerative Colitis (UC) 1.6 3.1 3.5 1.7 1.7 1.9
Major Depression (MDD) 0.2 0.2 0.5 -0.7 -0.3 0.2
Reaction Time 0.2 0.4 1.2 -1.1 -0.1 0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.1 -0.8 -1.1 -0.2
Breast Cancer 0.1 0.3 0.6 0.0 0.8 0.5
Ovarian Cancer 1.6 2.1 3.0 0.7 -1.7 -1.7
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.4 0.6 0.7 0.7 -0.6 -0.8
Bipolar Disorder (2011) 0.5 0.4 1.0 1.0 -0.0 -0.6
Body Mass Index (BMI) (2010) 1.1 1.5 2.5 0.6 -1.6 -1.3
Coronary Artery Disease (CAD) 0.1 0.1 0.1 0.4 0.2 -0.2
Crohns Disease (2012) 0.7 1.2 3.2 0.0 -1.8 -0.6
Mean Putamen Volume 0.2 0.2 0.4 -0.1 0.7 0.5
Fasting Glucose 1.3 1.5 1.8 1.1 1.4 1.2
HbA1C 0.2 0.2 0.3 -0.3 -0.5 -0.5
HDL Cholesterol 0.3 0.4 0.8 0.6 0.5 0.9
LDL Cholesterol 0.4 0.6 0.9 -1.0 0.8 0.4
Lupus 2.3 3.5 4.5 1.2 2.1 2.1
Neuroticism (2016) 0.7 1.0 1.9 0.4 -0.9 -1.4
Primary Biliary Cirrhosis 0.1 0.1 0.2 -0.5 0.4 0.1
Rheumatoid Arthritis 0.4 0.6 0.8 0.7 0.7 0.9
Schizophrenia (2014) 0.3 0.7 1.1 0.3 -1.0 -0.9
Triglycerides 0.7 1.1 1.7 -0.4 -1.2 -1.3
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.9 0.9 0.3 -0.1
Ulcerative Colitis 0.5 0.7 1.7 1.3 0.5 0.6
Blood Eosinophil Count 0.1 0.5 1.4 1.2 0.2 0.3
Blood Platelet Count 0.4 4.3 9.7 3.1 -1.2 -1.2
Blood Red Count 0.1 0.6 1.0 -1.0 -0.6 -0.5
Blood White Count 0.2 1.3 2.3 -0.5 1.5 1.2
Heel T-Score 0.4 3.2 6.6 -1.6 0.5 2.6
BMI 0.4 2.5 3.2 1.2 -1.8 -1.7
Height 0.2 4.8 5.3 2.2 -2.3 -2.0
Waist Hip Ratio (WHR) 0.2 0.9 2.5 -0.2 -1.6 -0.3
Systolic Blood Pressure 4.0 20.2 38.6 -0.2 6.2 4.7
Smoking Status 0.0 0.0 0.0 -0.0 -0.2 0.2
Allergy or Eczema 1.1 3.0 3.9 1.8 -2.0 -1.4
Cardiovascular Disease 1.4 4.7 8.8 -0.3 3.0 2.3
Hypothyroidism (self reported) 0.5 1.2 1.8 -1.3 1.2 0.5
Respiratory disease 1.8 4.1 8.3 -0.8 -2.9 -1.9
Type 2 Diabetes (T2D) (2018) 2.0 3.8 7.2 1.0 2.7 1.8
Lung FEV1/FVC ratio 0.4 2.0 3.2 1.6 1.8 0.1
Lung FVC 0.6 3.1 5.3 0.6 -1.9 -2.3
Neuroticism 0.8 1.9 3.4 1.2 -1.0 -1.9
Chronotype (morning person) 3.0 6.9 8.8 -1.8 3.0 2.9
Hair Pigment 0.1 3.1 4.5 -0.9 2.0 2.1
Tanning 0.3 3.6 6.9 -0.6 -2.6 -1.9
Hand grip strength (left) 0.2 0.6 1.5 -0.1 -1.2 -0.5
Number of treatments/medications taken 0.2 0.4 1.1 1.1 -0.2 0.2
Average weekly spirits intake 1.0 1.3 3.8 0.0 -2.0 0.0
Sensitivity / hurt feelings 0.2 0.3 0.5 0.1 -0.5 -0.7
Frequency of depressed mood in last 2 weeks 1.0 1.4 1.7 1.3 -0.9 -1.3
Hearing difficulty/problems: Yes 0.3 0.4 0.6 -0.8 -0.6 -0.4
Relative age of first facial hair 1.0 2.1 3.2 1.8 -0.7 -1.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.5 1.2 0.2 -0.5
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 0.2 0.6 -0.2
Ever had hysterectomy (womb removed) 2.1 2.4 4.5 0.1 2.1 1.6
Systolic blood pressure, automated reading 2.7 7.9 14.6 -0.7 3.8 2.9
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.8 -0.1 0.9 0.5
Angina 0.3 0.4 0.9 0.0 1.0 0.6
Medication for hormone replacement therapy 0.3 0.4 0.6 0.7 0.8 0.2
Vitamin and mineral supplements 1.1 1.5 2.1 1.3 -0.8 -1.5
Supplements: Zinc 0.6 0.7 1.5 0.5 0.4 1.2
Medication: Co-codamol 0.5 0.5 1.2 1.1 0.6 0.0
Medication: Metformin 2.1 3.0 4.8 1.3 2.2 1.6
Diabetes (father) 0.9 1.1 1.7 0.3 1.2 1.3
Diabetes (mother) 0.6 0.8 1.2 -0.5 -1.0 -1.1
Severe depression (siblings) 0.2 0.2 0.7 0.2 -0.8 -0.1
Pack years adult smoking proportion 1.2 1.9 2.2 1.3 1.5 1.2
Impedance of leg (right) 0.3 1.2 2.0 -1.4 1.0 0.8
Leg fat-free mass (left) 1.3 6.8 8.8 3.0 -2.1 -2.7
Trunk fat percentage 0.1 0.2 0.4 0.6 0.4 0.2
Hand grip strength (right) 0.6 1.7 4.5 -0.2 -2.1 -0.9
Townsend deprivation index at recruitment 0.8 1.1 1.9 0.4 1.1 1.4
Current tobacco smoking 0.5 0.8 1.7 -0.4 -1.3 -0.6
Average weekly fortified wine intake 0.2 0.2 0.4 0.1 -0.6 -0.5
Maternal smoking around birth 0.2 0.2 0.6 0.2 -0.3 -0.8
Fed-up feelings 0.4 0.8 2.1 -1.5 0.1 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.0 0.9 -0.9 -1.4
Relative age voice broke 0.6 0.9 2.0 1.4 -0.3 -0.9
Taking other prescription medications 0.6 0.9 2.0 0.4 -0.8 -1.4
Age when periods started (menarche) 0.3 0.6 0.9 -0.5 -0.9 -0.8
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.8 0.9 0.6 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.8 -1.4 -0.5 0.8
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.6 1.6 -0.8 -0.7
Qualifications: CSEs or equivalent 0.2 0.3 0.6 0.8 0.0 -0.5
Serious illness, injury or assault to yourself 0.2 0.3 0.4 0.7 0.5 -0.4
High blood pressure 1.2 3.3 6.0 0.1 2.4 2.0
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.5 0.7 -0.6 -0.3
Multivitamins +/- minerals 3.4 4.3 6.0 -2.5 1.4 2.2
Stomach or abdominal pain in last month 0.3 0.4 0.9 1.0 0.5 0.3
Supplements: Glucosamine 0.1 0.1 0.4 -0.1 -0.6 -0.2
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.1 0.1 -0.1 -0.3
Medication: Atenolol 2.1 2.6 4.4 -1.3 2.1 1.4
Medication: Levothyroxine sodium 1.1 1.9 3.1 -0.7 1.4 1.8
Sitting height 1.0 7.0 7.8 2.8 -2.3 -2.8
Chronic bronchitis/emphysema (father) 0.1 0.1 0.3 -0.5 0.1 0.2
High blood pressure (mother) 0.7 1.0 2.2 1.5 0.5 -0.7
Body mass index (BMI) 0.1 0.3 0.8 0.9 0.0 -0.4
Impedance of leg (left) 0.3 1.6 2.8 -1.7 0.8 1.1
Leg predicted mass (left) 1.3 6.8 8.8 3.0 -2.1 -2.7
Trunk fat mass 0.2 0.8 1.8 1.3 -0.3 -0.7
Waist circumference 0.1 0.3 0.6 0.3 -0.5 -0.8
Number of incorrect matches in round 0.3 0.5 1.2 1.1 0.2 0.5
Past tobacco smoking 0.1 0.1 0.3 -0.1 -0.6 -0.3
Alcohol usually taken with meals 0.1 0.2 0.5 -0.2 -0.1 0.7
Nervous feelings 0.3 0.5 1.4 -1.2 0.5 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.4 -0.4 0.6 -0.1
Hearing difficulty/problems with background noise 0.2 0.3 0.8 -0.9 -0.5 0.1
Hair/balding pattern: Pattern 2 1.6 2.0 4.2 -2.1 -1.3 0.1
Had menopause 2.3 2.8 6.7 -2.6 1.0 1.0
Had other major operations 1.0 1.2 2.1 -1.5 1.0 0.7
Forced vital capacity (FVC) 2.3 8.8 12.4 1.5 -3.5 -3.5
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 4.5 -2.1 -0.1 1.0
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 2.1 -1.5 -0.6 -0.8
Qualifications: None of the above 0.9 2.0 2.5 -1.3 1.6 1.3
Financial difficulties in last 2 years 0.3 0.5 1.0 0.6 -1.0 0.1
Mouth/teeth dental problems 0.8 1.2 2.1 -1.5 0.8 0.8
Heart attack 1.0 1.2 2.9 -0.3 1.7 0.8
Allergy 0.6 1.5 2.8 -1.0 1.7 0.8
Pain all over the body in last month 0.0 0.1 0.1 -0.2 0.3 0.0
Diabetes (self-reported) 2.3 3.5 6.8 0.0 2.6 1.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.1 0.2 0.9 1.1
Medication: Ramipril 1.4 1.9 2.9 -1.3 1.7 1.0
Medication: Simvastatin 0.5 0.8 1.5 -1.2 1.0 -0.0
Fluid intelligence score 0.2 0.3 0.6 -0.5 -0.8 -0.4
Illnesses of siblings 2.6 3.6 8.5 -0.3 -2.9 -1.5
Neuroticism score 0.5 0.9 2.3 0.1 -0.7 -1.5
Weight 0.6 2.9 3.4 1.9 -1.4 -1.8
Impedance of arm (right) 0.3 1.6 2.5 -1.6 0.6 1.3
Arm fat percentage (right) 0.0 0.2 0.2 0.4 0.5 0.4
Trunk fat-free mass 1.9 11.2 15.4 3.0 -3.0 -3.9
Hip circumference 0.2 1.0 2.3 0.3 -0.8 -1.5
Time employed in main current job 0.6 0.7 0.8 -0.8 0.7 0.9
Alcohol intake versus 10 years previously 0.9 1.4 2.8 0.4 1.1 1.7
Father’s age at death 0.7 0.9 2.4 -0.6 -1.6 -0.1
Worrier / anxious feelings 1.3 2.4 5.5 -2.4 1.2 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.8 0.3 -1.5 -2.2
Falls in the last year 0.9 1.2 3.3 1.8 0.4 -0.1
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 0.5 -0.8 -0.1
Number of live births 2.1 3.0 4.0 -1.2 2.0 1.9
Forced expiratory volume in 1-second (FEV1) 1.4 4.9 8.1 1.3 -2.2 -2.8
Pulse rate 0.8 1.4 3.8 1.9 -0.4 -0.6
Happiness 0.5 0.6 1.5 1.2 -0.3 -0.4
Noisy workplace 1.5 1.8 2.7 1.1 -1.2 -1.6
Qualifications: A levels/AS levels or equivalent 1.8 4.1 6.0 1.3 -2.5 -2.1
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 4.2 0.3 2.1 1.2
Mouth/teeth dental problems: Dentures 0.6 1.0 1.1 -1.1 1.0 1.0
Asthma 1.0 2.0 3.8 -0.8 -1.9 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.3 -0.8 -1.1 0.3
Medication: Cholesterol lowering 0.3 0.5 1.0 0.7 1.0 -0.1
Depression (self-reported) 0.3 0.4 0.7 -0.8 -0.5 0.3
Medication: Lansoprazole 0.2 0.2 0.6 0.1 -0.1 -0.8
Prospective memory result 1.8 2.2 3.4 -0.9 1.6 1.8
Lung cancer (father) 3.1 3.6 5.6 1.0 -2.4 -2.1
Illnesses of mother 1.1 1.4 3.5 -0.8 0.3 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.5 5.2 1.7 -1.6 -2.3
Pulse wave Arterial Stiffness index 1.0 1.2 2.4 1.5 0.9 0.7
Impedance of arm (left) 0.2 0.8 1.3 -0.9 0.4 1.2
Arm fat mass (right) 0.2 1.0 1.8 1.3 -0.6 -0.9
Trunk predicted mass 2.0 11.2 15.4 3.0 -3.0 -3.9
Standing height 1.1 10.6 13.3 2.5 -3.5 -3.6
Length of working week for main job 0.6 0.7 1.3 -0.6 -1.2 -0.6
Exposure to tobacco smoke at home 0.1 0.2 0.3 0.5 -0.4 0.3
Breastfed as a baby 5.7 7.0 9.7 2.2 -2.6 -3.1
Tense / ‘highly strung’ 0.9 1.5 2.6 -1.6 0.9 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 4.4 -2.1 -0.4 -0.2
Hair/balding pattern: Pattern 4 0.7 1.7 2.5 -1.1 -1.2 -1.6
Birth weight of first child 3.3 5.9 10.5 -0.7 -3.2 -2.6
Peak expiratory flow (PEF) 1.8 4.3 7.4 -0.7 -2.2 -2.7
Pulse wave reflection index 0.2 0.3 0.7 0.1 0.4 0.8
Ever highly irritable/argumentative for 2 days 2.5 3.0 5.7 -0.1 -1.9 -2.4
Loud music exposure frequency 5.3 5.8 11.0 1.6 -1.9 -3.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.9 0.2 -1.7 -1.1
Mouth/teeth dental problems: Bleeding gums 3.0 3.9 8.4 2.9 -1.4 -1.1
Blood clot in the leg (DVT) 0.7 0.9 1.4 -0.1 1.1 1.2
Medication: Paracetamol 0.5 0.8 2.2 1.5 0.4 -0.1
Headache pain in last month 0.4 0.7 1.3 0.1 1.1 0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.0 -0.1 -1.4 -0.7
Glaucoma (self-reported) 2.0 2.3 4.8 1.4 2.2 0.0
Gout (self-reported) 0.8 1.2 2.5 -0.9 -1.6 -0.5
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 2.1 -0.9 1.4 1.3
Medication: Amlodipine 0.1 0.1 0.2 -0.3 -0.4 -0.1
Medication: Ventolin 100micrograms inhaler 2.6 3.3 6.7 -0.8 -2.6 -1.6
Birth weight 1.3 2.8 5.8 0.1 -2.4 -1.7
Chronic bronchitis/emphysema (mother) 0.9 1.0 1.6 0.7 -1.0 -1.3
High blood pressure (siblings) 3.2 4.6 8.3 -1.1 2.9 2.0
Forced vital capacity (FVC), Best measure 1.3 4.7 7.0 1.2 -2.4 -2.6
Body fat percentage 0.1 0.3 0.4 0.5 0.6 0.5
Leg fat percentage (right) 0.1 0.2 0.6 -0.2 0.8 0.1
Arm fat-free mass (right) 1.5 7.9 11.3 3.4 -1.9 -2.9
Exposure to tobacco smoke outside home 0.2 0.3 0.8 0.9 0.1 -0.2
Comparative body size at age 10 0.3 0.9 1.8 1.3 -0.2 -0.9
Number of full brothers 0.3 0.4 0.8 0.1 0.9 0.6
Worry too long after embarrassment 0.3 0.5 0.9 0.9 0.5 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.5 -0.2 -0.6 -1.2
Wheeze or whistling in the chest in last year 0.3 0.6 1.6 -0.1 -1.3 0.2
Number of children fathered 0.9 1.0 1.4 -0.5 1.1 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.2 1.1 1.0 0.9
Age at first live birth 0.1 0.2 0.5 0.7 -0.1 -0.2
Pulse wave peak to peak time 1.0 1.1 1.5 -1.2 -1.0 -0.9
Health satisfaction 0.6 0.8 1.3 -0.1 -1.1 -1.0
Shortness of breath walking on level ground 0.2 0.2 0.3 0.5 -0.6 -0.4
Qualifications: College or University degree 1.0 3.2 5.4 2.3 -1.4 -1.4
Eye problems/disorders: None of the above 1.5 1.8 3.4 -1.8 0.3 1.3
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.8 0.2 0.9 -0.2
Emphysema/chronic bronchitis 2.1 2.4 5.2 -0.2 -2.3 -1.4
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 -0.8 0.4 0.5
Neck or shoulder pain in last month 2.9 4.1 8.4 -0.1 2.0 2.9
Medication: Blood pressure 0.7 1.3 1.5 -1.1 1.2 1.0
Angina (self-reported) 0.2 0.3 0.6 0.0 0.8 0.5
Migraine (self-reported) 0.4 0.5 0.9 -0.1 -0.9 -0.8
Medication: Ibuprofen 0.5 0.5 0.9 -0.4 -0.8 0.9
Medication: Allopurinol 1.1 1.5 3.8 -0.2 -1.9 -0.8
Medication: Omeprazole 0.8 0.9 1.4 0.9 -0.7 -1.2
Medication: Seretide 50 evohaler 0.3 0.4 1.1 0.0 0.0 1.1
Mean time to correctly identify matches 0.3 0.5 1.6 -1.2 -0.0 0.3
Heart disease (mother) 0.3 0.4 0.6 -0.6 0.7 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.4 4.0 7.8 -0.7 -2.8 -1.9
Whole body fat mass 0.1 0.6 1.4 1.2 -0.2 -0.5
Leg fat mass (right) 0.1 0.4 0.9 1.0 0.1 -0.5
Arm predicted mass (right) 1.5 7.9 9.9 3.1 -2.1 -3.0
Pulse rate, automated reading 0.6 1.9 5.4 2.3 -0.1 -0.5
Alcohol intake frequency. 0.9 2.1 3.3 0.7 -1.8 -1.5
Comparative height size at age 10 1.3 7.2 13.4 0.9 -3.7 -2.7
Number of full sisters 0.6 0.7 2.0 -1.4 0.0 0.1
Suffer from ‘nerves’ 0.6 1.0 1.7 -0.4 -1.0 -1.3
Overall health rating 0.1 0.3 0.6 0.4 -0.1 -0.8
Chest pain or discomfort 0.2 0.4 1.0 -1.0 -0.1 0.1
Had major operations 0.5 0.6 0.8 -0.9 -0.9 -0.3
Age at last live birth 1.1 1.6 2.6 0.0 1.6 1.5
Family relationship satisfaction 1.1 1.3 1.8 0.7 -1.3 -1.4
Leg pain on walking 0.1 0.1 0.3 0.2 0.5 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.3 -0.6 0.0 -0.0
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.6 -0.5 -0.5 -0.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.3 -1.1 -0.0 0.2
Medication: Aspirin 0.2 0.3 0.7 -0.8 -0.1 -0.5
Supplements: Vitamin C 0.2 0.2 0.4 0.2 -0.4 -0.6
Knee pain experienced in last month 3.0 4.6 6.2 2.2 2.5 1.7
Hypertension (Self-reported) 0.7 2.1 3.8 -0.3 1.9 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.3 0.4 -0.5 -1.1
Illnesses of father: Heart disease 0.1 0.1 0.2 0.1 0.3 -0.5
Illnesses of siblings: Diabetes 0.2 0.2 0.3 0.4 0.5 0.4
Smoking status: Previous 2.1 3.1 5.2 0.3 2.3 2.0
Forced expiratory volume in 1-second (FEV1), predicted 1.9 4.0 6.8 1.0 -2.0 -2.6
Whole body fat-free mass 1.7 9.4 12.1 3.0 -2.7 -3.5
Leg fat-free mass (right) 1.2 6.6 8.3 2.9 -2.2 -2.6
Arm fat percentage (left) 0.1 0.4 0.9 0.9 0.4 0.3
Average weekly red wine intake 0.4 0.6 1.6 0.1 1.3 0.3
Handedness (chirality/laterality): Left-handed 1.1 1.3 2.1 -0.3 1.5 1.3
Mood swings 0.3 0.5 1.1 0.4 1.1 0.2
Loneliness, isolation 0.6 0.8 1.3 1.0 0.1 -1.1
Long-standing illness, disability or infirmity 0.1 0.2 0.4 0.6 -0.1 -0.4
Ever had bowel cancer screening 0.2 0.2 0.4 0.6 -0.3 -0.3
Diabetes diagnosed by doctor 3.2 5.2 10.0 0.7 3.2 2.2
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 4.6 1.1 -2.1 0.2
Friendships satisfaction 0.2 0.2 0.4 -0.4 0.1 -0.6
Qualifications: nursing, teaching 0.7 1.0 3.0 1.7 -0.1 -0.3
Commuting to job workplace: Walk 1.2 1.3 2.9 -0.7 0.6 1.7
Eye problems/disorders: Cataract 1.4 1.6 2.5 0.5 -1.4 -1.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.0 1.0 -0.6 -0.8
Medication for cholesterol 1.3 2.0 3.3 0.0 -1.8 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 2.7 -1.4 1.6 1.0
Back pain experienced in last month 0.7 1.1 2.3 1.5 0.5 0.8
Mineral and other dietary supplements 0.3 0.4 0.8 0.6 0.2 -0.9
Breast cancer (self-reported) 0.2 0.3 0.8 -0.9 0.1 0.2
Asthma (self-reported) 1.1 2.2 4.0 -0.5 -2.0 -1.5
Osteoporosis (self-reported) 2.6 3.2 5.2 -0.6 2.0 2.3
Osteoarthritis (self-reported) 1.2 1.5 2.7 0.5 1.3 1.6
Medication: Aspirin 0.2 0.3 0.6 -0.7 -0.2 -0.5
Medication: Gliclazide 1.1 1.2 1.9 -0.4 1.4 1.3
Illnesses of father: None of the above (group 1) 0.7 0.9 1.3 1.1 -1.0 -0.6
Smoking status: Current 0.8 1.3 2.7 -0.2 -1.6 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 2.2 0.4 -1.4 -1.5
Whole body water mass 1.6 9.4 11.9 3.1 -2.6 -3.4
Leg predicted mass (right) 1.2 6.6 7.9 2.8 -2.3 -2.6
Arm fat mass (left) 0.3 1.4 2.9 1.7 -0.6 -0.9
Number of self-reported non-cancer illnesses 0.2 0.3 0.6 0.8 0.4 0.1
Average weekly champagne plus white wine intake 0.3 0.5 1.1 1.1 -0.2 0.5
Miserableness 1.7 2.9 4.5 0.0 -2.0 -2.1
Guilty feelings 0.8 1.2 2.0 1.0 -0.8 -1.4
Wears glasses or contact lenses 1.0 1.2 3.2 1.8 -0.4 -0.5
Ever taken oral contraceptive pill 4.3 4.8 9.2 -0.1 -3.0 -2.3
Hearing aid user 0.8 0.9 1.4 1.0 1.2 0.7
Mother’s age at death 1.0 1.3 3.6 -1.9 -0.4 -0.2
Financial situation satisfaction 0.1 0.1 0.3 -0.3 -0.5 -0.1
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.0 0.1 -1.0 -0.6
Commuting to job workplace: Public transport 0.1 0.1 0.3 0.1 -0.5 0.1
Eye problems/disorders: Glaucoma 2.2 2.6 4.0 2.0 2.0 -0.3
Medication: Blood pressure 0.8 1.6 2.2 0.6 1.5 1.5
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.9 1.4 0.3 -0.6
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.7 -1.3 0.3 0.5
High cholesterol (Self-reported) 0.1 0.1 0.2 0.3 0.4 0.1
Medication: Bendroflumethiazide 1.7 2.5 3.0 -1.7 1.7 1.3
Medication: Paracetamol 0.7 1.1 2.9 1.7 0.5 -0.1
Medication: Lisinopril 1.0 1.3 1.5 1.2 1.0 1.2
Medication: Atorvastatin 0.4 0.5 1.4 1.2 0.3 0.3
Illnesses of father: High blood pressure 2.6 3.2 5.7 -0.5 2.4 1.9
Alcohol drinker status: Never 0.3 0.3 0.9 1.0 -0.0 -0.0
Ever smoked 0.1 0.2 0.5 -0.2 -0.2 -0.7
Basal metabolic rate 1.4 8.0 9.8 2.9 -2.4 -3.1
Leg fat percentage (left) 0.1 0.3 0.6 -0.3 0.8 0.6
Arm fat-free mass (left) 1.2 5.9 7.8 2.3 -2.1 -2.8
Number of operations (self-reported) 0.1 0.1 0.3 -0.6 -0.1 -0.2
Average weekly beer plus cider intake 0.5 0.7 1.4 0.4 0.7 1.2
Irritability 2.2 3.7 6.0 -0.3 -2.2 -2.4
Risk taking 1.6 2.3 4.4 0.2 1.6 2.1
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.0 1.2 0.1 -1.4
Fractured/broken bones in last 5 years 0.6 0.8 1.2 0.6 0.9 1.1
Age started oral contraceptive pill 0.4 0.5 0.9 -0.6 0.5 0.9
Diastolic blood pressure, automated reading 0.5 1.7 2.4 0.7 1.6 1.5
Ever depressed for a whole week 2.1 2.6 4.8 -2.2 -0.8 -1.6
Unable to work because of sickness or disability 0.2 0.3 0.6 0.2 0.7 0.5
Commuting to job workplace: Cycle 0.7 0.8 1.0 -1.0 0.9 0.9
Myopia 0.2 0.4 0.6 0.1 0.7 0.8
Vascular/heart problems diagnosed by doctor 1.5 4.1 8.3 0.2 -2.9 -2.0
Cholesterol lowering medication 3.0 4.5 6.8 -1.5 2.0 2.6
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.9 0.6 -0.6 -1.0
Pain experienced in last month 2.0 3.3 4.1 -1.7 -2.0 -1.7
Supplements: Calcium 2.3 2.5 3.8 -1.6 1.2 1.9
Basal cell carcinoma (self-reported) 0.7 0.8 1.3 -0.3 -1.1 -1.0
Heart attack/myocardial infarction (self-reported) 1.3 1.7 3.9 -0.4 2.0 1.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 -0.2 0.8 0.7
Heart disease (siblings) 1.7 2.0 5.7 0.3 2.4 0.5
Alcohol drinker status: Previous 0.4 0.4 0.9 -0.2 -0.9 -0.6
Pack years of smoking 1.1 1.6 1.8 1.4 1.3 1.1
Impedance of whole body 0.3 1.6 2.1 -1.5 0.8 1.5
Leg fat mass (left) 0.1 0.4 1.0 1.0 0.1 -0.3
Arm predicted mass (left) 1.2 5.9 8.0 2.3 -2.1 -2.8