Hub : Genes

AC068499.10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.3720	0.1380	3.6e-03	0.008	NA	0.171	NA	0.035	1.9e-01	NA	1.3e-05	NA	3.5e-02
2	GTEx	Esophagus Mucosa	0.1620	0.0550	4.1e-04	0.067	NA	0.061	NA	0.078	2.9e-05	NA	6.8e-05	NA	6.7e-06
3	GTEx	Muscle Skeletal	0.0962	0.0305	2.9e-05	0.070	NA	0.064	NA	0.069	2.0e-07	NA	6.4e-07	NA	2.5e-07
4	GTEx	Testis	0.3780	0.0680	1.4e-10	0.407	NA	0.365	NA	0.398	2.1e-19	NA	4.4e-17	NA	6.8e-19

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.6	0.8	0.7	-0.2	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	1.8	1.4	0.9	-0.7	-1.0
Depressed Affect (Nagel 2018)	2.2	4.7	8.6	1.6	-2.9	-2.5	-1.1
Depression (Nagel 2018)	2.0	3.0	7.7	0.4	-2.8	-1.8	1.0
Intelligence (Savage-Jansen 2018)	2.2	6.9	15.3	-0.0	3.9	2.1	2.8
Neuroticism (Nagel 2018)	1.3	3.0	4.9	1.9	-2.2	-1.5	-1.0
Schizophrenia (2018)	0.5	1.1	2.5	1.6	0.6	-0.8	-0.9
Schizophrenia vs Biploar Disorder	2.2	2.9	7.6	-0.8	-2.8	-1.4	1.2
Worry (Nagel 2018)	1.2	2.6	7.7	2.8	-1.0	-0.3	-1.3
Alzheimer’s Disease (in mother)	0.8	1.0	2.4	-0.8	0.8	0.4	1.6
Alzheimer’s Disease (in father)	0.2	0.2	0.5	-0.7	-0.1	-0.3	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-1.0	0.6	0.1	1.2
Crohns Disease (2017)	0.5	1.1	2.6	-0.7	-1.6	-0.9	0.7
Irritable Bowel Disease (IBD)	0.2	0.6	2.1	0.1	-1.5	-0.3	-0.0
Ulcerative Colitis (UC)	0.3	0.6	1.1	0.7	-0.8	0.2	-1.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.2	2.2	3.1	1.8	-1.3	1.4	1.4
Verbal and Numeric Reasoning (VNR)	2.4	5.7	15.1	-0.8	3.9	2.2	1.5
Breast Cancer	0.4	1.1	1.8	-1.3	-0.2	1.0	1.2
Ovarian Cancer	2.1	2.8	6.8	0.8	1.6	2.6	-1.1
Prostate Cancer	1.3	1.9	3.4	-0.7	1.4	1.2	-1.9
Age at First Birth	1.1	1.5	4.7	0.6	-0.9	0.5	2.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.8	3.8	6.1	2.5	1.7	0.8	-2.4
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.5	0.7	1.4	0.5	-1.2	-1.1	-0.0
Mean Putamen Volume	0.2	0.2	0.6	-0.8	0.2	0.4	-0.1
Fasting Glucose	1.4	1.7	3.5	-1.7	0.5	-0.1	1.9
HbA1C	0.6	0.6	1.6	1.3	-0.2	-0.3	0.9
HDL Cholesterol	0.7	1.2	1.7	-1.2	1.3	1.3	0.1
LDL Cholesterol	2.2	3.5	5.2	-2.1	-1.9	-2.3	-1.0
Lupus	2.6	3.9	9.3	1.4	3.1	2.0	0.3
Neuroticism (2016)	0.4	0.5	1.4	1.2	0.2	0.2	-0.8
Primary Biliary Cirrhosis	2.2	3.1	5.3	1.7	2.0	2.3	0.1
Rheumatoid Arthritis	2.3	3.2	6.6	1.1	2.6	2.2	0.5
Schizophrenia (2014)	0.3	0.7	1.3	0.7	0.2	-1.0	-1.1
Triglycerides	0.7	1.1	2.0	0.6	-1.4	-1.4	0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.3	0.4	0.8	0.4	-0.4	0.6	-0.9
Blood Eosinophil Count	0.6	4.7	16.9	1.1	-0.2	0.8	4.1
Blood Platelet Count	0.7	8.4	22.8	-2.6	-4.8	-0.7	1.9
Blood Red Count	0.4	3.7	9.2	0.6	-3.0	-2.2	0.7
Blood White Count	0.8	6.2	19.2	1.2	-4.4	-1.9	0.9
Heel T-Score	0.4	3.5	9.4	1.8	0.4	3.1	-1.1
BMI	2.4	13.6	47.7	2.1	0.2	-1.6	-6.9
Height	0.2	4.3	6.8	2.6	1.2	-2.5	1.7
Waist Hip Ratio (WHR)	6.4	28.6	81.5	-3.5	-4.4	-9.0	-1.0
Systolic Blood Pressure	0.4	2.2	6.0	2.5	-1.5	-0.2	0.7
Smoking Status	0.4	1.0	1.6	-0.1	1.0	1.3	-1.2
Allergy or Eczema	0.9	2.5	6.6	-0.9	2.6	1.5	-0.6
Cardiovascular Disease	0.5	1.6	5.5	2.4	-0.2	0.4	-0.8
Hypothyroidism (self reported)	3.3	7.6	13.8	0.8	3.7	3.5	1.9
Respiratory disease	0.9	2.1	5.1	-0.8	2.3	1.3	-1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	0.4	0.7	1.4	0.4
Lung FEV1/FVC ratio	1.8	9.0	16.4	-1.0	-4.0	-3.2	-2.9
Lung FVC	1.4	7.1	17.6	1.2	2.9	4.2	-1.0
Neuroticism	0.9	2.2	4.0	2.0	-1.4	-1.6	-0.7
Chronotype (morning person)	1.7	4.0	8.0	2.6	0.8	2.8	-0.9
Hair Pigment	0.0	0.8	2.8	-1.7	-0.1	-0.3	-0.5
Tanning	0.4	5.1	11.6	1.1	-3.4	-2.7	0.3
Hand grip strength (left)	0.6	1.6	3.9	0.5	2.0	-0.7	1.3
Number of treatments/medications taken	1.2	2.2	5.0	2.2	1.1	1.2	-0.9
Average weekly spirits intake	3.3	4.1	5.0	-1.5	-2.2	-2.2	-2.0
Sensitivity / hurt feelings	1.3	2.2	4.6	0.4	-1.6	-2.1	-1.3
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.3	0.3	-1.8	-1.1	1.5
Hearing difficulty/problems: Yes	0.1	0.2	0.4	-0.7	0.3	-0.2	-0.2
Relative age of first facial hair	1.4	2.8	5.8	-1.9	2.4	1.0	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.0	0.2	0.9	0.2	1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	1.0	-0.7	0.3	-0.6
Ever had hysterectomy (womb removed)	1.0	1.2	2.1	1.4	-0.6	-0.3	-1.5
Systolic blood pressure, automated reading	0.5	1.3	3.2	1.8	-1.0	-0.9	-0.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.6	0.6	1.6	0.7	-0.3
Angina	0.6	0.8	1.2	-0.3	-1.0	-1.0	1.1
Medication for hormone replacement therapy	0.3	0.4	0.8	0.5	0.1	0.7	-0.9
Vitamin and mineral supplements	1.2	1.7	5.0	0.0	-1.0	-0.8	-2.2
Supplements: Zinc	1.5	1.7	4.7	-2.2	-1.0	-0.4	0.9
Medication: Co-codamol	0.8	0.9	3.1	1.8	-0.3	-0.7	-0.2
Medication: Metformin	0.6	0.9	1.5	0.3	1.2	1.2	-0.8
Diabetes (father)	0.8	1.0	1.1	0.8	-1.0	-1.0	1.0
Diabetes (mother)	1.3	1.7	3.4	0.4	-1.7	-1.8	0.3
Severe depression (siblings)	2.4	2.7	6.8	0.6	1.9	2.6	0.1
Pack years adult smoking proportion	0.3	0.5	1.1	1.0	-0.7	0.1	-0.6
Impedance of leg (right)	3.5	17.0	37.6	-1.9	-6.1	-4.3	2.9
Leg fat-free mass (left)	1.2	6.1	13.6	1.3	3.0	-0.2	-3.7
Trunk fat percentage	4.6	18.3	30.5	0.5	-4.1	-5.1	-5.5
Hand grip strength (right)	0.3	0.7	2.0	0.7	1.4	-0.4	0.4
Townsend deprivation index at recruitment	1.1	1.6	6.2	0.1	0.0	-0.3	2.5
Current tobacco smoking	0.4	0.7	0.9	-1.0	-1.0	-0.9	0.1
Average weekly fortified wine intake	2.9	3.4	5.9	-2.4	-2.3	-1.3	0.9
Maternal smoking around birth	0.7	1.0	1.5	0.8	0.9	1.1	-1.2
Fed-up feelings	1.9	3.5	8.5	2.9	-1.4	-1.5	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.2	0.3	-1.5	-0.5	1.8
Relative age voice broke	1.7	2.6	6.2	-0.2	2.0	2.5	0.3
Taking other prescription medications	3.0	4.6	5.5	2.1	2.3	2.2	-1.9
Age when periods started (menarche)	1.6	3.8	6.7	-1.1	2.1	1.7	2.6
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.9	-1.0	-0.7	0.3	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	-0.5	-0.6	-0.0	-0.4
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	4.5	0.1	-2.1	-1.8	1.8
Qualifications: CSEs or equivalent	0.0	0.1	0.1	-0.0	-0.3	-0.1	0.3
Serious illness, injury or assault to yourself	0.3	0.3	1.2	-0.0	-0.3	-0.2	1.1
High blood pressure	0.2	0.6	2.4	1.6	0.0	-0.0	0.3
Hayfever, allergic rhinitis or eczema	1.7	3.6	8.5	-1.1	2.9	2.2	-0.2
Multivitamins +/- minerals	1.2	1.5	2.9	0.6	1.4	1.7	0.7
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.2	0.6	-0.0	0.3
Supplements: Glucosamine	1.8	2.3	5.4	-0.9	2.3	1.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	0.1	-0.2	0.8	-0.7
Medication: Atenolol	0.7	0.9	1.9	1.4	-1.1	-0.3	0.3
Medication: Levothyroxine sodium	2.9	5.0	8.7	1.6	2.4	3.0	1.7
Sitting height	0.1	0.5	1.0	0.1	0.5	-1.0	-0.9
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	-1.0	0.8	0.1	-0.2
High blood pressure (mother)	0.1	0.2	0.5	0.1	0.4	0.4	0.7
Body mass index (BMI)	2.5	10.4	37.3	1.2	0.1	-1.7	-6.1
Impedance of leg (left)	3.2	15.3	33.9	-1.8	-5.8	-3.8	3.1
Leg predicted mass (left)	1.2	6.2	13.8	1.3	3.0	-0.2	-3.7
Trunk fat mass	3.5	14.9	33.2	1.0	-2.5	-4.4	-5.8
Waist circumference	3.5	12.9	30.5	0.3	-1.6	-4.3	-5.5
Number of incorrect matches in round	2.9	4.8	7.7	1.7	-2.6	-1.4	2.8
Past tobacco smoking	1.5	2.7	4.6	-1.6	-2.1	-2.0	-0.1
Alcohol usually taken with meals	1.0	1.7	4.7	-1.3	0.0	-0.6	2.2
Nervous feelings	1.1	2.1	6.7	2.6	-0.2	1.0	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.5	1.2	-0.9	0.1	1.2
Hearing difficulty/problems with background noise	1.0	1.6	5.0	0.6	-0.1	-1.0	2.2
Hair/balding pattern: Pattern 2	0.9	1.1	4.3	-2.1	-0.0	0.3	0.0
Had menopause	0.3	0.4	0.6	0.3	-0.8	-0.6	-0.7
Had other major operations	1.3	1.5	2.6	1.6	-0.9	-1.0	-1.3
Forced vital capacity (FVC)	0.6	2.3	4.8	0.2	2.2	1.6	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-1.1	-0.2	0.6	-0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.4	0.8	-1.2	0.6	-0.3
Qualifications: None of the above	2.8	6.0	14.9	-0.8	-3.9	-2.7	-1.1
Financial difficulties in last 2 years	0.4	0.6	1.6	0.8	0.3	-0.3	1.3
Mouth/teeth dental problems	4.3	6.7	10.8	-1.7	-3.3	-2.5	2.6
Heart attack	1.2	1.6	3.2	1.8	-0.9	0.6	1.4
Allergy	1.2	2.7	5.9	1.6	-2.4	-1.2	1.1
Pain all over the body in last month	3.0	3.2	4.7	-2.1	-2.2	-2.0	0.3
Diabetes (self-reported)	0.4	0.6	1.7	1.3	0.2	0.6	0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.1	-0.3	1.1	1.8	0.6
Medication: Ramipril	0.9	1.2	4.1	2.0	-0.4	0.6	0.6
Medication: Simvastatin	1.5	2.1	3.1	-0.1	-1.8	-1.7	1.6
Fluid intelligence score	1.7	3.5	7.7	-0.4	2.8	2.0	1.5
Illnesses of siblings	1.8	2.5	9.0	-3.0	-0.6	-0.7	0.4
Neuroticism score	1.2	2.4	4.6	2.1	-1.6	-1.6	0.2
Weight	1.8	8.9	27.9	1.5	0.5	-2.2	-5.3
Impedance of arm (right)	4.1	19.0	40.9	-2.3	-6.4	-4.4	3.2
Arm fat percentage (right)	3.7	14.5	35.9	0.5	-2.5	-4.0	-6.0
Trunk fat-free mass	1.4	8.2	19.3	2.0	4.4	1.1	-2.9
Hip circumference	2.0	8.5	29.7	2.0	0.5	-0.2	-5.5
Time employed in main current job	1.7	2.0	3.2	0.1	-1.8	-1.8	1.3
Alcohol intake versus 10 years previously	0.3	0.5	1.7	-0.2	-0.4	-0.3	1.3
Father’s age at death	1.3	1.7	3.5	-1.4	-0.2	-1.1	-1.9
Worrier / anxious feelings	0.4	0.8	1.6	1.0	-0.9	-0.3	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	0.9	0.7	1.0	0.8	0.7
Falls in the last year	0.3	0.4	0.8	0.9	-0.5	-0.1	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	-0.2	1.0	0.5	0.1
Number of live births	0.6	0.8	2.1	-0.6	-0.4	-0.7	-1.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.3	-0.5	0.6	0.3	0.4
Pulse rate	1.1	1.8	5.5	-0.8	-0.8	-2.3	-0.6
Happiness	0.6	0.7	2.0	0.5	-0.5	-0.5	1.4
Noisy workplace	0.0	0.0	0.1	0.0	0.0	-0.3	0.2
Qualifications: A levels/AS levels or equivalent	3.9	8.7	21.5	0.9	4.6	3.3	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	1.1	-0.0	0.7	-1.2
Mouth/teeth dental problems: Dentures	2.9	4.9	13.0	1.3	1.7	1.5	-3.6
Asthma	1.2	2.4	6.7	-0.3	2.6	1.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	-0.0	0.3	-1.0	-0.1
Medication: Cholesterol lowering	0.2	0.3	1.1	0.2	0.0	0.2	1.0
Depression (self-reported)	1.3	1.6	5.0	2.2	0.4	1.0	0.0
Medication: Lansoprazole	1.1	1.2	3.1	0.2	-1.8	-1.3	-0.3
Prospective memory result	2.3	2.8	8.4	0.4	-2.9	-1.6	-0.2
Lung cancer (father)	1.0	1.2	3.8	0.9	-0.3	0.4	-1.9
Illnesses of mother	0.5	0.6	1.4	0.4	1.2	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	-0.1	0.4	0.6	-0.7
Pulse wave Arterial Stiffness index	1.1	1.2	4.6	0.4	0.4	0.2	-2.1
Impedance of arm (left)	2.7	12.7	26.5	-2.2	-5.1	-3.4	2.8
Arm fat mass (right)	2.9	12.1	35.3	1.0	-1.3	-3.2	-5.9
Trunk predicted mass	1.4	8.1	19.1	2.0	4.4	1.1	-2.9
Standing height	0.1	1.2	2.0	1.1	0.8	-1.4	1.0
Length of working week for main job	2.2	2.5	3.2	1.5	1.7	1.8	-1.4
Exposure to tobacco smoke at home	1.4	1.6	2.7	1.3	-1.4	-0.3	1.6
Breastfed as a baby	2.3	2.9	6.2	-0.4	2.0	2.5	1.1
Tense / ‘highly strung’	0.3	0.5	1.5	1.2	-0.6	0.0	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.9	1.4	-0.1	2.0	-0.2
Hair/balding pattern: Pattern 4	0.5	1.2	1.9	1.1	0.1	1.4	-1.4
Birth weight of first child	0.8	1.4	2.8	-0.2	1.7	-0.2	-1.6
Peak expiratory flow (PEF)	0.5	1.1	2.2	-1.5	-1.1	-1.0	-0.1
Pulse wave reflection index	1.4	1.7	5.6	0.1	-0.3	1.1	-2.4
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.0	-0.1	-1.0	-0.8	0.0
Loud music exposure frequency	1.8	1.9	3.7	1.9	0.4	1.5	-1.2
Qualifications: O levels/GCSEs or equivalent	2.9	4.6	10.2	0.5	3.2	2.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.3	0.5	-0.3	-0.0
Blood clot in the leg (DVT)	1.4	1.8	2.9	-1.5	-1.7	-1.2	-0.9
Medication: Paracetamol	0.4	0.7	1.4	0.4	1.1	-0.3	-1.2
Headache pain in last month	2.8	4.7	11.7	1.2	3.4	2.3	-0.7
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.2	0.4	-0.7	-0.5
Glaucoma (self-reported)	0.5	0.6	2.0	-1.4	-0.2	-0.6	-0.2
Gout (self-reported)	1.5	2.1	7.2	0.3	1.0	-0.3	-2.7
Hypothyroidism/myxoedema (self-reported)	3.0	5.8	10.9	1.2	3.3	2.8	1.7
Medication: Amlodipine	0.1	0.2	0.5	0.7	-0.1	0.3	-0.2
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.5	-1.0	1.6	0.8	-0.6
Birth weight	1.7	3.6	12.2	1.3	3.5	0.3	-0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	-0.5	0.5	0.5	-1.3
High blood pressure (siblings)	0.7	1.0	2.2	1.5	1.0	0.8	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.1	3.9	0.8	1.9	2.0	0.1
Body fat percentage	4.6	18.0	35.2	0.2	-3.8	-4.8	-5.9
Leg fat percentage (right)	4.8	17.4	33.7	0.5	-3.6	-4.7	-5.8
Arm fat-free mass (right)	1.8	9.0	15.4	2.4	3.8	1.0	-3.9
Exposure to tobacco smoke outside home	0.4	0.5	1.4	1.2	-0.2	0.8	-0.0
Comparative body size at age 10	1.3	3.6	7.0	2.3	0.8	1.1	-2.6
Number of full brothers	0.5	0.7	1.1	1.1	1.0	-0.6	0.2
Worry too long after embarrassment	0.1	0.2	0.5	-0.0	-0.5	-0.3	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.1	0.5	0.9	0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.4	0.4	0.6	-0.7	-0.4
Number of children fathered	1.8	2.0	5.1	-0.7	-0.9	-2.3	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.5	-0.0	0.7	-0.8
Age at first live birth	1.3	2.3	7.5	-0.4	0.5	1.1	2.7
Pulse wave peak to peak time	1.1	1.3	4.8	-0.3	-0.4	-0.4	2.2
Health satisfaction	0.6	0.8	1.3	0.4	1.1	0.7	-1.1
Shortness of breath walking on level ground	0.3	0.3	1.1	-0.1	0.2	-1.0	-0.3
Qualifications: College or University degree	3.7	11.7	17.0	2.2	4.0	4.1	3.0
Eye problems/disorders: None of the above	0.4	0.4	0.7	-0.8	-0.4	0.8	0.2
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.0	1.4	0.7	1.1	1.7
Emphysema/chronic bronchitis	1.2	1.4	3.6	-1.9	-0.4	-1.2	0.7
Medication for pain relief, constipation, heartburn	0.5	0.9	2.0	-1.4	-0.2	0.7	1.0
Neck or shoulder pain in last month	0.9	1.3	2.7	-0.1	1.5	0.5	1.6
Medication: Blood pressure	0.6	1.1	2.5	1.2	0.0	1.6	0.6
Angina (self-reported)	0.3	0.5	0.8	0.0	-0.8	-0.7	0.9
Migraine (self-reported)	1.1	1.3	4.4	0.7	0.5	0.3	-2.1
Medication: Ibuprofen	0.6	0.7	2.1	-0.6	-0.2	-1.4	-0.7
Medication: Allopurinol	0.6	0.8	1.6	0.2	1.2	0.3	-1.2
Medication: Omeprazole	0.7	0.8	2.6	1.6	0.1	0.1	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.2	0.5	0.7	-0.4
Mean time to correctly identify matches	1.5	2.8	5.7	2.4	-0.8	2.2	0.5
Heart disease (mother)	0.2	0.2	0.5	-0.7	-0.6	0.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-1.3	-0.3	-0.3	0.8
Whole body fat mass	3.6	14.9	37.0	0.8	-2.2	-4.1	-6.1
Leg fat mass (right)	3.5	13.6	35.7	1.0	-1.6	-3.9	-6.0
Arm predicted mass (right)	1.3	6.6	11.8	2.0	3.3	0.3	-3.4
Pulse rate, automated reading	2.2	7.2	18.7	-1.5	-2.8	-4.3	-0.2
Alcohol intake frequency.	0.2	0.5	1.4	-0.1	-0.5	-0.5	1.2
Comparative height size at age 10	1.3	7.2	15.5	2.0	-2.4	-3.9	-1.9
Number of full sisters	0.8	0.9	3.2	-0.2	-0.6	-0.3	1.8
Suffer from ‘nerves’	0.8	1.2	4.5	2.1	-0.3	0.1	0.5
Overall health rating	0.8	1.8	4.7	-0.5	-1.1	-2.2	0.9
Chest pain or discomfort	1.1	1.6	3.2	-0.3	-1.3	-1.8	1.2
Had major operations	1.9	2.2	3.6	0.7	1.9	1.1	-1.9
Age at last live birth	1.2	1.8	3.1	-0.8	1.3	1.3	1.8
Family relationship satisfaction	0.3	0.4	0.8	0.9	-0.4	0.0	0.8
Leg pain on walking	1.2	1.5	3.3	1.8	0.8	0.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.3	-0.8	-0.7	-1.2	-1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.1	-0.3	0.6	-1.1	-0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.3	-1.8	0.0	-0.1	0.4
Medication: Aspirin	0.4	0.5	1.3	1.2	-0.5	-0.0	0.6
Supplements: Vitamin C	0.9	1.1	3.2	-0.8	0.3	-0.7	1.8
Knee pain experienced in last month	0.5	0.8	2.1	-0.1	-1.4	-1.1	-0.3
Hypertension (Self-reported)	0.2	0.5	2.0	1.4	-0.0	-0.1	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	1.1	-0.6	-0.5	-0.6
Illnesses of father: Heart disease	1.0	1.3	2.0	1.2	-1.1	0.9	1.4
Illnesses of siblings: Diabetes	1.1	1.4	3.5	1.9	0.9	-0.0	-1.1
Smoking status: Previous	2.2	3.3	5.3	1.8	2.0	2.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.8	-1.3	-0.0	-1.3	1.3
Whole body fat-free mass	1.3	7.5	15.7	1.8	4.0	0.6	-3.3
Leg fat-free mass (right)	1.2	6.3	13.0	1.3	3.6	0.5	-3.2
Arm fat percentage (left)	3.5	13.9	39.9	0.5	-2.0	-3.4	-6.3
Average weekly red wine intake	0.5	0.7	2.0	-0.6	0.3	0.7	1.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	0.1	0.8	1.2	0.3
Mood swings	1.0	1.8	2.4	1.6	-1.2	-1.5	-1.0
Loneliness, isolation	0.9	1.2	1.9	1.3	-1.4	-0.8	0.9
Long-standing illness, disability or infirmity	0.2	0.4	1.2	0.4	-0.1	-0.2	1.1
Ever had bowel cancer screening	0.2	0.3	0.8	0.3	0.9	-0.3	-0.0
Diabetes diagnosed by doctor	0.3	0.6	1.3	1.2	0.0	0.8	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	0.1	0.7	1.1	-0.3
Friendships satisfaction	1.0	1.2	2.0	1.0	0.9	1.0	1.4
Qualifications: nursing, teaching	1.2	1.9	3.1	0.4	1.8	1.7	1.1
Commuting to job workplace: Walk	2.0	2.2	5.8	0.9	1.2	2.4	-0.7
Eye problems/disorders: Cataract	0.2	0.3	0.8	0.4	0.4	-0.9	0.0
Mouth/teeth dental problems: Mouth ulcers	4.5	7.2	15.4	2.2	3.9	2.9	0.4
Medication for cholesterol	0.8	1.1	1.6	-1.0	1.3	1.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.4	1.2	1.2	0.8	-0.7
Back pain experienced in last month	0.8	1.2	2.1	-1.4	-1.2	-1.2	-0.2
Mineral and other dietary supplements	0.7	1.0	2.8	0.5	-1.7	-1.0	-0.2
Breast cancer (self-reported)	0.4	0.5	0.8	-0.3	-0.9	-0.8	-0.7
Asthma (self-reported)	1.0	1.9	5.0	-0.3	2.2	1.2	-1.1
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.1	-0.5	-0.0	-0.4
Osteoarthritis (self-reported)	1.1	1.4	2.8	-1.3	0.6	1.0	-1.7
Medication: Aspirin	0.3	0.4	1.6	1.3	-0.0	0.2	0.3
Medication: Gliclazide	1.1	1.2	2.6	0.6	0.9	1.6	-1.0
Illnesses of father: None of the above (group 1)	0.9	1.1	2.5	-1.6	-0.4	-1.2	0.6
Smoking status: Current	0.2	0.3	0.5	-0.7	-0.5	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.9	-1.4	-0.2	0.3	-0.3
Whole body water mass	1.3	7.5	15.8	1.9	4.0	0.6	-3.2
Leg predicted mass (right)	1.1	6.1	13.0	1.3	3.6	0.4	-3.1
Arm fat mass (left)	2.8	11.6	35.8	1.0	-0.9	-3.0	-6.0
Number of self-reported non-cancer illnesses	2.0	3.4	7.4	1.0	2.7	1.9	-1.2
Average weekly champagne plus white wine intake	2.0	2.7	7.1	0.5	1.8	2.7	-0.4
Miserableness	1.5	2.7	7.0	-0.5	-2.6	-1.8	-0.3
Guilty feelings	1.1	1.7	4.3	2.1	0.4	1.4	0.6
Wears glasses or contact lenses	0.6	0.7	1.7	0.6	-0.1	0.8	-1.3
Ever taken oral contraceptive pill	1.3	1.4	4.1	0.1	1.2	2.0	0.4
Hearing aid user	0.4	0.5	1.6	0.6	-1.3	0.1	0.2
Mother’s age at death	1.7	2.1	4.3	-0.9	-1.4	-2.1	1.1
Financial situation satisfaction	1.2	1.5	4.2	-0.4	-2.0	-1.2	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.5	-0.6	0.2	-0.1	1.2
Commuting to job workplace: Public transport	1.0	1.2	3.3	0.6	0.1	1.0	-1.8
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.4	0.4	-0.5	0.3
Medication: Blood pressure	1.3	2.5	5.4	1.1	-2.3	-1.8	0.4
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.0	-1.2	1.4	0.8	-0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.7	-1.0	-0.4	-1.3	0.8
High cholesterol (Self-reported)	1.3	2.3	5.5	-0.1	-1.7	-2.4	0.9
Medication: Bendroflumethiazide	0.2	0.2	0.8	0.2	-0.9	0.2	0.2
Medication: Paracetamol	0.7	1.1	2.0	0.9	1.2	-0.1	-1.4
Medication: Lisinopril	0.0	0.1	0.1	0.4	-0.2	0.1	-0.0
Medication: Atorvastatin	0.5	0.7	1.1	0.6	-1.0	-1.1	-0.5
Illnesses of father: High blood pressure	2.0	2.5	3.5	0.9	1.9	1.8	-1.6
Alcohol drinker status: Never	1.2	1.4	2.2	-1.0	-1.5	-0.9	1.3
Ever smoked	1.4	2.4	4.2	0.5	2.1	1.3	1.9
Basal metabolic rate	1.2	6.7	13.7	1.7	3.2	-0.1	-3.7
Leg fat percentage (left)	4.4	15.8	33.4	0.6	-3.2	-4.4	-5.8
Arm fat-free mass (left)	1.2	6.2	11.7	2.3	2.8	-0.3	-3.4
Number of operations (self-reported)	2.6	3.9	11.1	1.1	1.5	1.1	-3.3
Average weekly beer plus cider intake	2.6	3.7	9.1	3.0	0.4	1.1	-2.1
Irritability	0.7	1.1	2.1	-0.2	-1.1	-1.5	1.1
Risk taking	1.2	1.8	3.1	1.8	0.1	1.4	1.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.5	-0.0	1.2	-0.0	0.1
Fractured/broken bones in last 5 years	0.6	0.7	1.6	0.6	0.9	1.3	0.3
Age started oral contraceptive pill	0.3	0.3	1.0	0.2	-1.0	0.2	0.4
Diastolic blood pressure, automated reading	0.9	2.8	5.4	2.1	-0.2	-1.2	-2.3
Ever depressed for a whole week	0.4	0.4	1.4	0.1	-0.6	1.2	0.0
Unable to work because of sickness or disability	0.4	0.6	1.4	1.2	0.3	-0.1	0.9
Commuting to job workplace: Cycle	0.6	0.7	1.9	-0.5	-0.2	0.9	1.4
Myopia	3.4	5.0	14.3	-0.4	2.3	3.8	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.7	2.2	-1.5	-0.0	-0.1	-0.6
Cholesterol lowering medication	2.8	4.1	8.4	-0.2	-2.9	-2.8	-0.0
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.0	1.7	0.1	0.1	-1.6
Pain experienced in last month	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.2
Supplements: Calcium	1.1	1.3	2.1	-1.0	1.4	-0.0	1.4
Basal cell carcinoma (self-reported)	1.4	1.7	2.4	1.2	1.6	1.1	-1.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.5	1.9	-0.8	0.8	1.4
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.8	-1.7	-1.5	-0.8	-0.9
Heart disease (siblings)	0.9	1.2	4.0	2.0	0.0	0.8	0.1
Alcohol drinker status: Previous	2.0	2.3	4.8	1.5	1.5	2.2	-0.4
Pack years of smoking	0.5	0.7	1.2	1.1	-1.1	-0.2	-0.6
Impedance of whole body	3.6	18.2	40.6	-2.2	-6.4	-4.0	3.3
Leg fat mass (left)	3.4	13.3	37.3	1.0	-1.5	-3.6	-6.1
Arm predicted mass (left)	1.3	6.5	11.7	2.2	3.0	0.1	-3.4