[Hub]/) : Traits : Blood Platelet Count :

chr6:108,994,161-111,190,694

Best TWAS P=2.09e-20 · Best GWAS P=8.52e-38 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CD164 0.11 0.07 blup 376 0.10 1.6e-12 5.915 -7.6 3.5e-14 -0.40 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous FIG4 0.12 0.08 lasso 4 0.07 4.4e-06 -7.143 -7.1 1.5e-12 -0.32 0.96 0.00 TRUE
3 GTEx Adipose Subcutaneous SMPD2 0.14 0.10 lasso 10 0.12 2.3e-10 5.832 9.2 3.3e-20 0.46 0.97 0.03 FALSE
4 GTEx Adipose Subcutaneous AK9 0.12 0.09 lasso 7 0.10 2.1e-08 6.431 -7.5 6.3e-14 -0.21 0.95 0.00 TRUE
5 GTEx Adipose Subcutaneous RP11-425D10.10 0.10 0.08 enet 22 0.07 4.4e-06 6.431 5.7 9.8e-09 0.07 0.95 0.00 FALSE
6 GTEx Adipose Visceral Omentum AK9 0.10 0.02 enet 27 0.04 2.7e-03 6.141 -5.8 6.4e-09 -0.11 0.76 0.01 FALSE
7 GTEx Adipose Visceral Omentum RP11-425D10.10 0.16 0.10 lasso 6 0.06 7.2e-04 6.431 6.6 3.4e-11 0.10 0.63 0.04 FALSE
8 GTEx Adrenal Gland WASF1 0.22 -0.01 enet 20 0.03 2.2e-02 2.443 -5.9 3.9e-09 -0.10 0.06 0.43 FALSE
9 GTEx Adrenal Gland RP11-425D10.10 0.11 0.00 enet 11 0.02 4.9e-02 5.566 5.6 2.4e-08 0.23 0.15 0.33 FALSE
10 GTEx Artery Aorta SMPD2 0.10 0.04 enet 11 0.03 1.5e-02 6.333 7.1 1.3e-12 0.13 0.67 0.04 TRUE
11 GTEx Artery Aorta AK9 0.16 0.14 enet 32 0.14 3.7e-08 -7.117 -9.0 1.6e-19 -0.35 1.00 0.00 TRUE
12 GTEx Artery Aorta RP11-425D10.10 0.12 0.06 lasso 4 0.09 1.4e-05 6.431 5.6 2.5e-08 -0.01 0.90 0.00 FALSE
13 GTEx Artery Coronary SMPD2 0.11 0.09 lasso 4 0.07 1.9e-03 5.806 6.1 9.5e-10 0.24 0.36 0.04 FALSE
14 GTEx Artery Coronary AK9 0.27 0.26 enet 18 0.28 5.2e-10 -7.354 -8.0 1.4e-15 -0.26 1.00 0.00 FALSE
15 GTEx Artery Coronary RP11-425D10.10 0.31 0.00 enet 20 0.01 1.3e-01 -1.830 5.8 6.4e-09 0.34 0.04 0.05 FALSE
16 GTEx Artery Tibial FIG4 0.18 0.01 enet 41 0.07 4.1e-06 0.096 -5.8 7.8e-09 -0.23 0.27 0.27 FALSE
17 GTEx Artery Tibial MICAL1 0.08 0.02 lasso 3 0.01 6.5e-02 6.549 6.5 8.3e-11 0.10 0.42 0.06 FALSE
18 GTEx Artery Tibial AK9 0.13 0.12 enet 18 0.13 3.5e-10 6.309 -6.6 4.8e-11 -0.12 1.00 0.00 FALSE
19 GTEx Brain Caudate basal ganglia AK9 0.20 0.16 enet 16 0.17 1.1e-05 6.640 -6.4 1.8e-10 -0.19 0.69 0.02 FALSE
20 GTEx Brain Cerebellar Hemisphere AK9 0.24 0.17 lasso 3 0.11 1.0e-03 6.431 -6.3 3.2e-10 -0.10 0.33 0.05 FALSE
21 GTEx Brain Cortex AK9 0.21 0.03 enet 29 0.16 3.2e-05 6.640 -8.3 6.9e-17 -0.32 0.57 0.08 FALSE
22 GTEx Brain Frontal Cortex BA9 AK9 0.50 0.02 enet 47 0.15 1.1e-04 6.431 -6.3 2.9e-10 -0.20 0.25 0.04 FALSE
23 GTEx Brain Nucleus accumbens basal ganglia AK9 0.28 0.02 enet 22 0.09 1.8e-03 6.640 -6.0 1.9e-09 -0.18 0.23 0.09 FALSE
24 GTEx Breast Mammary Tissue AK9 0.17 0.13 enet 19 0.13 4.0e-07 6.431 -5.2 2.5e-07 -0.02 0.99 0.00 FALSE
25 GTEx Breast Mammary Tissue RP11-425D10.10 0.12 0.12 lasso 1 0.08 5.1e-05 6.431 6.4 1.3e-10 0.10 0.94 0.00 FALSE
26 GTEx Breast Mammary Tissue (Male) AK9 0.10 0.03 lasso 3 -0.01 5.4e-01 6.333 -6.5 7.1e-11 -0.11 0.06 0.06 FALSE
27 GTEx Breast Mammary Tissue (Female) AK9 0.12 0.15 lasso 1 0.12 1.9e-04 6.431 -6.4 1.3e-10 -0.10 0.15 0.05 FALSE
28 GTEx Breast Mammary Tissue (Female) RP11-425D10.10 0.14 0.04 lasso 10 0.02 6.5e-02 6.577 6.9 6.8e-12 0.16 0.06 0.07 FALSE
29 GTEx Cells Transformed fibroblasts WASF1 0.11 0.03 lasso 5 0.02 6.0e-03 4.217 -5.1 2.7e-07 0.09 0.60 0.03 FALSE
30 GTEx Cells Transformed fibroblasts CD164 0.14 0.07 lasso 6 0.05 1.9e-04 10.404 9.3 2.1e-20 0.83 0.90 0.03 TRUE
31 GTEx Cells Transformed fibroblasts SMPD2 0.20 0.13 lasso 9 0.15 3.1e-11 5.827 5.6 1.7e-08 0.12 1.00 0.00 FALSE
32 GTEx Cells Transformed fibroblasts AK9 0.14 0.17 lasso 4 0.15 2.4e-11 -7.209 -7.2 4.2e-13 -0.32 1.00 0.00 FALSE
33 GTEx Colon Sigmoid FIG4 0.17 0.11 lasso 9 0.03 3.7e-02 6.484 -6.5 9.8e-11 -0.10 0.25 0.04 FALSE
34 GTEx Colon Sigmoid RP11-425D10.10 0.13 0.00 enet 14 0.02 5.2e-02 6.640 5.7 1.2e-08 0.01 0.41 0.03 FALSE
35 GTEx Colon Transverse SMPD2 0.19 0.25 lasso 5 0.24 1.1e-11 5.827 5.9 2.8e-09 0.20 1.00 0.00 FALSE
36 GTEx Colon Transverse AK9 0.26 0.12 enet 46 0.12 2.6e-06 6.431 -5.3 1.4e-07 0.05 0.97 0.00 FALSE
37 GTEx Colon Transverse RP11-425D10.10 0.12 0.13 enet 21 0.14 2.2e-07 6.567 6.5 1.0e-10 0.12 1.00 0.00 FALSE
38 GTEx Esophagus Gastroesophageal Junction SMPD2 0.11 0.06 lasso 6 0.06 4.1e-03 5.806 6.0 1.6e-09 0.25 0.36 0.04 FALSE
39 GTEx Esophagus Gastroesophageal Junction AK9 0.19 0.10 enet 25 0.13 1.7e-05 -7.342 -6.6 4.9e-11 -0.25 0.86 0.01 FALSE
40 GTEx Esophagus Mucosa SMPD2 0.17 0.20 lasso 10 0.22 2.2e-14 6.550 6.6 4.9e-11 0.14 1.00 0.00 TRUE
41 GTEx Esophagus Mucosa AK9 0.11 0.06 lasso 13 0.04 6.0e-04 6.640 -7.3 2.4e-13 -0.21 0.84 0.01 FALSE
42 GTEx Esophagus Mucosa RP11-425D10.10 0.09 0.13 lasso 5 0.12 1.1e-08 6.431 6.5 6.4e-11 0.11 1.00 0.00 FALSE
43 GTEx Esophagus Muscularis CD164 0.04 0.02 enet 6 0.01 1.0e-01 6.222 6.9 6.7e-12 0.12 0.26 0.03 FALSE
44 GTEx Esophagus Muscularis AK9 0.41 0.22 enet 60 0.29 5.7e-18 6.309 -7.5 7.9e-14 -0.25 1.00 0.00 FALSE
45 GTEx Heart Atrial Appendage RP11-425D10.10 0.12 0.11 lasso 5 0.07 4.0e-04 6.431 7.2 5.1e-13 0.19 0.71 0.02 FALSE
46 GTEx Heart Left Ventricle AK9 0.17 0.04 enet 11 0.13 2.3e-07 6.651 -6.1 1.3e-09 0.02 0.94 0.00 FALSE
47 GTEx Heart Left Ventricle RP11-425D10.10 0.13 0.04 enet 34 0.03 9.2e-03 6.333 5.6 1.7e-08 0.01 0.37 0.03 FALSE
48 GTEx Lung SMPD2 0.10 0.12 lasso 2 0.10 7.5e-08 5.827 5.8 5.9e-09 0.18 1.00 0.00 FALSE
49 GTEx Lung RP11-425D10.10 0.10 0.08 enet 24 0.07 6.4e-06 6.632 7.8 4.9e-15 0.18 0.99 0.00 FALSE
50 GTEx Muscle Skeletal WASF1 0.11 0.04 enet 22 0.05 7.8e-06 4.275 -5.4 6.0e-08 0.08 0.92 0.00 TRUE
51 GTEx Muscle Skeletal CD164 0.07 0.07 enet 15 0.06 3.7e-06 -7.326 -8.0 1.9e-15 -0.67 0.98 0.01 FALSE
52 GTEx Muscle Skeletal AK9 0.08 0.02 lasso 6 0.03 4.3e-04 -7.353 -8.1 4.8e-16 -0.26 0.86 0.03 FALSE
53 GTEx Nerve Tibial SMPD2 0.12 0.08 lasso 4 0.08 3.6e-06 5.639 5.9 3.0e-09 0.24 0.96 0.00 FALSE
54 GTEx Nerve Tibial AK9 0.18 0.15 enet 26 0.18 1.5e-12 6.431 -8.1 7.6e-16 -0.23 1.00 0.00 FALSE
55 GTEx Ovary RP11-425D10.10 0.15 0.10 lasso 5 0.02 9.0e-02 6.431 6.4 1.9e-10 0.10 0.22 0.06 FALSE
56 GTEx Skin Not Sun Exposed Suprapubic SMPD2 0.27 0.15 lasso 10 0.17 1.6e-09 6.431 5.7 1.2e-08 0.10 1.00 0.00 FALSE
57 GTEx Skin Not Sun Exposed Suprapubic RP11-425D10.10 0.20 0.27 lasso 5 0.27 5.5e-15 6.309 6.4 1.5e-10 0.12 1.00 0.00 FALSE
58 GTEx Skin Sun Exposed Lower leg SMPD2 0.19 0.19 lasso 12 0.24 1.6e-19 6.622 6.5 7.9e-11 0.14 1.00 0.00 FALSE
59 GTEx Skin Sun Exposed Lower leg AK9 0.14 0.12 lasso 3 0.14 1.9e-11 6.431 -6.2 4.5e-10 -0.08 1.00 0.00 FALSE
60 GTEx Skin Sun Exposed Lower leg RP11-425D10.10 0.19 0.23 enet 18 0.23 3.4e-19 6.309 7.9 2.5e-15 0.24 1.00 0.00 FALSE
61 GTEx Small Intestine Terminal Ileum RP11-425D10.10 0.16 0.07 lasso 9 0.06 1.5e-02 6.554 6.5 1.1e-10 0.19 0.11 0.06 FALSE
62 GTEx Spleen RP11-425D10.10 0.17 0.04 enet 26 0.12 4.7e-04 6.333 7.1 1.1e-12 0.33 0.24 0.18 TRUE
63 GTEx Stomach SMPD2 0.14 -0.01 lasso 5 -0.01 8.6e-01 5.303 8.0 1.0e-15 0.46 0.06 0.20 FALSE
64 GTEx Stomach RP11-425D10.10 0.25 0.10 lasso 6 0.09 3.0e-05 6.012 5.7 1.1e-08 0.16 0.90 0.00 FALSE
65 GTEx Testis ZBTB24 0.11 0.11 lasso 4 0.10 4.9e-05 6.431 -6.6 5.5e-11 -0.17 0.72 0.02 FALSE
66 GTEx Testis SMPD2 0.28 0.18 lasso 7 0.17 7.6e-08 5.827 5.2 2.5e-07 0.13 0.98 0.01 FALSE
67 GTEx Testis MICAL1 0.28 0.02 enet 25 0.02 4.2e-02 2.649 6.4 1.2e-10 0.22 0.16 0.04 FALSE
68 GTEx Thyroid PPIL6 0.17 0.05 lasso 4 0.12 4.4e-09 6.551 -5.3 1.0e-07 0.01 0.98 0.00 FALSE
69 GTEx Vagina RP11-425D10.10 0.42 0.22 lasso 19 0.17 9.0e-05 6.431 6.8 1.2e-11 0.13 0.53 0.03 FALSE
70 GTEx Whole Blood SMPD2 0.15 0.16 lasso 8 0.15 1.0e-13 5.827 5.3 9.8e-08 0.12 1.00 0.00 FALSE
71 GTEx Whole Blood RP11-425D10.10 0.04 0.03 enet 16 0.03 6.2e-04 6.141 6.7 2.6e-11 0.15 0.74 0.05 FALSE
72 METSIM Adipose AK9 0.05 0.03 lasso 6 0.02 1.0e-04 6.333 -7.5 8.2e-14 -0.19 0.97 0.00 FALSE
73 METSIM Adipose SMPD2 0.06 0.08 enet 14 0.08 2.0e-12 5.754 6.2 4.6e-10 0.20 1.00 0.00 FALSE
74 NTR Blood CD164 0.01 0.00 bslmm 372 0.00 2.0e-02 -3.706 8.1 5.6e-16 0.58 0.08 0.62 FALSE
75 ROSMAP Brain Pre-frontal Cortex ZBTB24 0.03 0.00 blup 389 0.00 7.3e-02 6.333 -6.9 4.0e-12 -0.20 0.32 0.02 FALSE
76 ROSMAP Brain Pre-frontal Cortex CD164 0.07 0.01 enet 16 0.05 1.6e-07 6.012 -9.2 2.3e-20 -0.45 0.72 0.15 FALSE
77 ROSMAP Brain Pre-frontal Cortex SMPD2 0.12 0.10 lasso 5 0.09 1.3e-11 5.832 5.2 2.3e-07 0.20 1.00 0.00 FALSE
78 ROSMAP Brain Pre-frontal Cortex AK9 0.08 0.06 bslmm 456 0.06 5.3e-08 6.306 -6.6 4.3e-11 -0.22 1.00 0.00 FALSE
79 YFS Blood CD164 0.03 0.01 blup 382 0.02 1.9e-07 -7.326 9.0 3.4e-19 0.57 0.97 0.02 FALSE
80 YFS Blood SMPD2 0.06 0.08 lasso 7 0.08 2.5e-24 5.832 5.9 2.9e-09 0.19 1.00 0.00 FALSE
81 The Cancer Genome Atlas Bladder Urothelial Carcinoma AKD1 0.08 0.06 blup 114 0.05 4.7e-05 6.635 -5.7 1.4e-08 -0.10 0.28 0.71 FALSE
82 The Cancer Genome Atlas Bladder Urothelial Carcinoma SMPD2 0.04 0.04 blup 43 0.05 3.9e-05 6.567 6.2 7.1e-10 0.10 0.07 0.88 FALSE
83 The Cancer Genome Atlas Breast Invasive Carcinoma SMPD2 0.04 0.07 lasso 4 0.07 8.8e-14 5.754 5.9 3.9e-09 0.19 0.81 0.19 FALSE
84 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma SMPD2 0.07 0.08 blup 45 0.07 2.3e-04 5.754 6.8 1.4e-11 0.20 0.07 0.84 FALSE
85 The Cancer Genome Atlas Colon Adenocarcinoma SMPD2 0.17 0.14 lasso 4 0.14 2.3e-08 5.915 6.0 2.5e-09 0.24 0.61 0.38 FALSE
86 The Cancer Genome Atlas Esophageal Carcinoma C6orf182 0.10 -0.01 blup 40 0.03 4.2e-02 10.172 8.8 2.1e-18 0.58 0.01 0.79 FALSE
87 The Cancer Genome Atlas Esophageal Carcinoma SMPD2 0.12 0.09 blup 41 0.07 2.6e-03 6.523 7.0 3.7e-12 0.14 0.05 0.60 FALSE
88 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma AKD1 0.07 0.06 blup 116 0.06 4.2e-07 6.348 -5.1 3.0e-07 -0.06 0.56 0.44 TRUE
89 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SMPD2 0.09 0.09 blup 42 0.10 2.1e-11 6.012 5.4 7.7e-08 0.20 0.88 0.12 FALSE
90 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma AKD1 0.11 0.08 lasso 5 0.10 5.8e-11 6.583 -5.5 3.2e-08 -0.04 0.15 0.85 FALSE
91 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FIG4 0.07 0.02 lasso 2 0.04 5.5e-05 -7.353 -6.2 4.3e-10 -0.20 0.00 0.98 FALSE
92 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SMPD2 0.05 0.07 lasso 4 0.06 9.6e-08 5.915 6.1 8.7e-10 0.23 0.45 0.55 FALSE
93 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma AKD1 0.11 0.06 lasso 3 0.06 2.7e-04 6.632 -6.6 3.2e-11 -0.15 0.67 0.30 FALSE
94 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SMPD2 0.12 0.15 enet 6 0.14 3.8e-08 5.754 5.8 6.8e-09 0.19 0.95 0.05 FALSE
95 The Cancer Genome Atlas Brain Lower Grade Glioma AKD1 0.12 0.11 lasso 6 0.12 9.8e-14 6.640 -7.0 2.0e-12 -0.15 0.62 0.38 FALSE
96 The Cancer Genome Atlas Brain Lower Grade Glioma MICAL1 0.08 0.11 lasso 4 0.12 1.8e-13 5.915 -5.9 3.7e-09 -0.23 0.97 0.03 FALSE
97 The Cancer Genome Atlas Brain Lower Grade Glioma ZBTB24 0.04 0.05 lasso 4 0.04 7.8e-06 6.583 -6.9 5.3e-12 -0.12 0.01 0.99 FALSE
98 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PPIL6 0.07 0.03 blup 53 0.02 5.8e-02 5.827 -6.1 1.0e-09 -0.16 0.03 0.21 FALSE
99 The Cancer Genome Atlas Lung Adenocarcinoma AKD1 0.05 0.03 blup 122 0.04 1.3e-05 7.452 -7.4 1.1e-13 -0.22 0.06 0.94 FALSE
100 The Cancer Genome Atlas Lung Adenocarcinoma SMPD2 0.06 0.09 enet 11 0.08 4.7e-10 5.754 5.2 2.3e-07 0.13 0.94 0.06 FALSE
101 The Cancer Genome Atlas Lung Squamous Cell Carcinoma AKD1 0.06 0.07 lasso 4 0.05 2.8e-06 6.222 -5.2 1.5e-07 -0.02 0.72 0.27 FALSE
102 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SMPD2 0.04 0.06 blup 45 0.06 8.9e-08 5.912 6.6 5.3e-11 0.20 0.46 0.54 FALSE
103 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma AKD1 0.04 0.03 blup 114 0.03 4.7e-03 6.648 -5.3 1.0e-07 -0.07 0.13 0.18 FALSE
104 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SMPD2 0.06 0.05 lasso 3 0.06 9.2e-05 5.827 5.5 3.9e-08 0.22 0.47 0.33 FALSE
105 The Cancer Genome Atlas Pancreatic Adenocarcinoma SMPD2 0.08 0.07 lasso 3 0.05 3.3e-03 5.827 5.8 6.0e-09 0.18 0.04 0.81 FALSE
106 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma SMPD2 0.10 0.04 lasso 2 0.07 1.2e-03 5.915 6.2 5.9e-10 0.26 0.02 0.59 TRUE
107 The Cancer Genome Atlas Prostate Adenocarcinoma SMPD2 0.08 0.13 lasso 3 0.13 2.4e-13 5.754 5.8 7.7e-09 0.18 0.98 0.02 FALSE
108 The Cancer Genome Atlas Rectum Adenocarcinoma SMPD2 0.13 0.08 lasso 2 0.06 1.5e-02 5.827 5.8 5.6e-09 0.18 0.01 0.49 FALSE
109 The Cancer Genome Atlas Stomach Adenocarcinoma SMPD2 0.07 0.07 blup 44 0.08 3.4e-06 6.583 6.7 2.3e-11 0.17 0.03 0.97 FALSE
110 The Cancer Genome Atlas Testicular Germ Cell Tumors SMPD2 0.23 0.13 lasso 5 0.17 1.4e-06 6.309 5.8 6.8e-09 0.10 0.02 0.98 FALSE
111 The Cancer Genome Atlas Thyroid Carcinoma CD164 0.03 0.01 blup 49 0.01 2.1e-02 5.832 9.0 1.8e-19 0.44 0.08 0.15 FALSE
112 The Cancer Genome Atlas Thyroid Carcinoma SMPD2 0.15 0.17 enet 14 0.18 9.4e-18 5.754 5.7 9.3e-09 0.21 0.98 0.02 FALSE