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chr13:113,139,568-115,106,996

Best TWAS P=4.69e-46 · Best GWAS P=2.04e-44 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CDC16	0.05	0.03	bslmm	208	0.04	2.4e-05	-14.0	-10.3	5.2e-25	0.76	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UPF3A	0.09	0.04	lasso	6	0.08	1.7e-09	-12.4	-6.4	1.2e-10	0.31	0.95	0.02	FALSE
3	GTEx	Adipose Subcutaneous	CDC16	0.17	0.17	lasso	4	0.19	3.6e-15	-13.7	-13.7	1.5e-42	0.99	0.02	0.98	FALSE
4	GTEx	Adipose Visceral Omentum	CDC16	0.12	0.11	lasso	4	0.09	1.5e-05	-14.0	-13.8	2.0e-43	0.98	0.01	0.99	FALSE
5	GTEx	Adipose Visceral Omentum	UPF3A	0.33	0.04	enet	31	0.14	1.5e-07	-3.1	-7.3	2.4e-13	0.37	0.57	0.29	FALSE
6	GTEx	Adrenal Gland	UPF3A	0.17	0.00	enet	27	0.06	3.9e-03	-3.5	-5.8	5.1e-09	0.44	0.02	0.36	FALSE
7	GTEx	Artery Aorta	CDC16	0.15	0.18	enet	10	0.17	1.6e-09	-13.9	-13.3	3.4e-40	0.97	0.01	0.99	FALSE
8	GTEx	Artery Aorta	UPF3A	0.38	0.24	enet	18	0.28	9.9e-16	-12.4	-10.3	4.9e-25	0.65	0.80	0.20	FALSE
9	GTEx	Artery Coronary	CDC16	0.41	0.02	enet	5	0.02	6.9e-02	-11.4	-13.1	5.9e-39	0.91	0.02	0.94	FALSE
10	GTEx	Artery Coronary	UPF3A	0.25	0.11	lasso	4	0.14	1.5e-05	-12.4	-10.0	2.0e-23	0.54	0.04	0.72	FALSE
11	GTEx	Artery Tibial	CDC16	0.23	0.26	lasso	8	0.25	2.8e-19	-13.7	-13.8	1.3e-43	0.99	0.01	0.99	FALSE
12	GTEx	Artery Tibial	UPF3A	0.33	0.25	enet	19	0.29	6.2e-23	-12.4	-11.0	2.3e-28	0.72	0.66	0.34	FALSE
13	GTEx	Brain Cerebellar Hemisphere	CDC16	0.17	0.10	lasso	9	0.17	3.5e-05	-13.7	-12.6	3.3e-36	0.92	0.02	0.96	FALSE
14	GTEx	Brain Cerebellum	CDC16	0.18	0.05	lasso	4	0.07	3.4e-03	-13.9	-13.4	3.4e-41	0.95	0.02	0.96	FALSE
15	GTEx	Brain Cortex	UPF3A	0.25	0.11	enet	13	0.10	1.2e-03	-11.5	8.6	5.9e-18	-0.58	0.08	0.11	FALSE
16	GTEx	Breast Mammary Tissue	CDC16	0.25	0.28	lasso	6	0.26	6.9e-14	-14.0	-13.4	4.5e-41	0.97	0.01	0.99	FALSE
17	GTEx	Breast Mammary Tissue	UPF3A	0.33	0.06	enet	18	0.18	9.7e-10	-13.9	-8.0	1.7e-15	0.59	0.02	0.98	FALSE
18	GTEx	Breast Mammary Tissue (Male)	CDC16	0.23	0.08	enet	11	0.09	3.8e-03	-12.3	-12.8	1.0e-37	0.85	0.04	0.85	FALSE
19	GTEx	Breast Mammary Tissue (Female)	CDC16	0.25	0.22	enet	28	0.22	3.6e-07	-14.0	-13.6	3.3e-42	0.92	0.01	0.98	FALSE
20	GTEx	Breast Mammary Tissue (Female)	UPF3A	0.32	0.16	lasso	13	0.17	1.2e-05	-13.9	-13.4	6.6e-41	0.91	0.02	0.98	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	CDC16	0.14	0.09	lasso	3	0.10	2.9e-04	-13.9	-14.1	2.5e-45	0.99	0.01	0.98	FALSE
22	GTEx	Cells Transformed fibroblasts	CDC16	0.17	0.13	lasso	6	0.15	4.6e-11	-13.9	-14.1	1.9e-45	0.98	0.01	0.99	FALSE
23	GTEx	Cells Transformed fibroblasts	UPF3A	0.49	0.12	lasso	8	0.44	1.3e-35	-12.4	-7.3	3.9e-13	0.46	0.96	0.04	FALSE
24	GTEx	Colon Sigmoid	UPF3A	0.15	0.10	lasso	8	0.08	8.3e-04	-13.9	-14.1	3.3e-45	0.97	0.02	0.97	FALSE
25	GTEx	Colon Transverse	CDC16	0.18	0.23	lasso	5	0.21	3.2e-10	-14.0	-13.9	4.7e-44	0.98	0.01	0.99	FALSE
26	GTEx	Colon Transverse	UPF3A	0.13	0.04	lasso	3	0.04	5.6e-03	-8.6	-12.0	3.9e-33	0.77	0.03	0.91	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	CDC16	0.09	0.05	lasso	2	0.02	5.7e-02	-14.0	-14.0	1.3e-44	1.00	0.01	0.92	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	UPF3A	0.20	0.07	lasso	6	0.06	4.5e-03	-13.9	-14.0	8.0e-45	0.99	0.01	0.95	FALSE
29	GTEx	Esophagus Mucosa	CDC16	0.35	0.46	lasso	6	0.46	1.0e-33	-14.0	-14.0	1.5e-44	1.00	0.01	0.99	FALSE
30	GTEx	Esophagus Mucosa	UPF3A	0.27	0.04	enet	19	0.21	2.9e-14	-12.4	-7.0	1.9e-12	0.41	0.54	0.44	FALSE
31	GTEx	Esophagus Muscularis	CDC16	0.12	0.09	lasso	6	0.13	3.2e-08	-11.1	-10.6	3.3e-26	0.88	0.02	0.98	FALSE
32	GTEx	Esophagus Muscularis	UPF3A	0.43	0.25	enet	33	0.37	8.8e-24	-12.4	-10.3	6.4e-25	0.66	0.06	0.94	FALSE
33	GTEx	Lung	CDC16	0.16	0.21	lasso	5	0.19	9.6e-15	-13.7	-13.7	6.5e-43	0.99	0.01	0.99	FALSE
34	GTEx	Muscle Skeletal	CDC16	0.05	0.06	lasso	1	0.05	9.2e-06	-13.7	-13.7	1.1e-42	0.99	0.02	0.98	FALSE
35	GTEx	Nerve Tibial	CDC16	0.23	0.23	enet	19	0.26	9.5e-19	-13.7	-13.1	5.1e-39	0.95	0.01	0.99	FALSE
36	GTEx	Nerve Tibial	UPF3A	0.29	0.06	lasso	7	0.11	2.8e-08	-12.4	-7.0	2.0e-12	0.37	0.55	0.38	FALSE
37	GTEx	Pancreas	CDC16	0.09	0.14	lasso	3	0.06	1.8e-03	-14.0	-14.0	2.3e-44	1.00	0.01	0.98	FALSE
38	GTEx	Prostate	CDC16	0.17	0.16	lasso	3	0.11	1.4e-03	-14.0	-14.0	2.2e-44	1.00	0.01	0.94	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	CDC16	0.35	0.42	enet	33	0.45	7.9e-27	-13.9	-13.3	1.2e-40	0.96	0.01	0.99	FALSE
40	GTEx	Skin Sun Exposed Lower leg	CDC16	0.31	0.33	lasso	7	0.33	4.1e-28	-13.9	-13.7	1.8e-42	0.98	0.01	0.99	FALSE
41	GTEx	Small Intestine Terminal Ileum	CDC16	0.16	0.04	lasso	9	0.03	6.1e-02	-14.0	-9.3	2.1e-20	0.78	0.02	0.77	FALSE
42	GTEx	Spleen	CDC16	0.25	0.19	lasso	7	0.21	4.9e-06	-13.9	-13.7	6.6e-43	0.98	0.02	0.97	FALSE
43	GTEx	Stomach	CDC16	0.12	0.06	enet	23	0.08	1.6e-04	-13.9	-12.5	8.6e-36	0.87	0.02	0.98	FALSE
44	GTEx	Testis	PCID2	0.21	0.18	lasso	3	0.18	2.5e-08	6.1	6.3	2.8e-10	0.02	0.03	0.97	FALSE
45	GTEx	Testis	CDC16	0.32	0.30	enet	26	0.35	4.4e-16	-14.0	-13.6	5.6e-42	0.94	0.01	0.99	FALSE
46	GTEx	Thyroid	CDC16	0.12	0.13	lasso	2	0.11	8.2e-09	-13.9	-13.9	4.9e-44	1.00	0.02	0.98	FALSE
47	GTEx	Thyroid	UPF3A	0.10	0.00	enet	17	0.01	5.7e-02	-13.9	-9.8	1.6e-22	0.62	0.02	0.72	FALSE
48	GTEx	Whole Blood	CDC16	0.31	0.20	lasso	5	0.20	4.4e-18	-13.9	-13.4	9.1e-41	0.98	0.01	0.99	FALSE
49	METSIM	Adipose	CDC16	0.18	0.27	enet	18	0.26	6.6e-39	-14.0	-13.6	3.6e-42	0.96	0.01	0.99	FALSE
50	METSIM	Adipose	UPF3A	0.24	0.12	blup	188	0.19	2.2e-27	-12.4	-5.4	5.9e-08	0.36	1.00	0.00	FALSE
51	NTR	Blood	CDC16	0.10	0.20	bslmm	209	0.20	3.1e-63	-13.9	-14.0	2.8e-44	1.00	0.01	0.99	FALSE
52	YFS	Blood	CDC16	0.28	0.54	enet	30	0.55	1.1e-220	-13.9	-13.7	1.1e-42	0.99	0.01	0.99	FALSE
53	YFS	Blood	UPF3A	0.21	0.17	enet	38	0.25	2.4e-82	-12.4	-9.0	2.9e-19	0.62	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CDC16	0.08	0.11	lasso	5	0.12	4.3e-10	-14.0	-13.6	4.6e-42	0.99	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PROZ	0.07	0.14	lasso	2	0.13	2.3e-11	6.3	-6.3	2.6e-10	0.00	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UPF3A	0.21	0.07	blup	32	0.14	7.6e-12	-12.4	-7.5	8.7e-14	0.46	0.43	0.57	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDC16	0.01	0.01	blup	49	0.01	1.1e-03	-13.7	-13.7	7.6e-43	0.97	0.01	0.96	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	PCID2	0.01	0.01	blup	46	0.01	2.6e-03	6.2	5.7	1.6e-08	0.03	0.02	0.74	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	PROZ	0.03	0.03	blup	39	0.03	2.7e-06	6.2	-6.3	2.5e-10	0.00	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	UPF3A	0.10	0.06	enet	15	0.10	4.7e-19	-3.4	-5.7	9.3e-09	0.33	1.00	0.00	FALSE
61	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PROZ	0.11	0.06	blup	39	0.10	1.3e-05	6.2	-6.2	6.2e-10	-0.04	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	CDC16	0.06	0.04	lasso	5	0.03	5.9e-03	-11.5	-13.1	5.2e-39	0.88	0.02	0.91	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	UPF3A	0.37	0.12	blup	32	0.14	2.9e-08	-12.4	-7.5	6.5e-14	0.39	0.68	0.25	FALSE
64	The Cancer Genome Atlas	Esophageal Carcinoma	PROZ	0.16	0.10	blup	38	0.13	7.4e-05	6.2	-6.3	2.1e-10	-0.03	0.01	0.98	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CDC16	0.05	0.08	lasso	4	0.08	7.2e-09	-13.9	-13.8	4.2e-43	0.99	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PROZ	0.02	0.01	lasso	1	0.01	1.2e-02	6.4	-6.4	2.0e-10	-0.01	0.01	0.93	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UPF3A	0.13	0.03	enet	16	0.11	1.9e-12	-12.4	-7.2	9.0e-13	0.43	0.46	0.49	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CDC16	0.05	0.04	blup	49	0.05	2.0e-06	-13.7	-14.0	1.9e-44	0.95	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PROZ	0.07	0.04	blup	39	0.03	8.6e-05	6.2	-5.5	3.7e-08	-0.01	0.01	0.99	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UPF3A	0.20	0.11	enet	12	0.17	4.3e-19	-12.4	-8.6	1.2e-17	0.50	1.00	0.00	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC16	0.04	0.01	blup	49	0.03	7.7e-03	-14.0	-13.0	1.3e-38	0.96	0.01	0.96	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UPF3A	0.24	0.08	blup	32	0.16	2.6e-09	-13.7	-8.9	8.0e-19	0.59	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	PROZ	0.03	0.05	enet	9	0.04	3.3e-05	6.3	-6.1	8.4e-10	-0.02	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Lung Adenocarcinoma	UPF3A	0.10	0.00	blup	32	0.05	3.6e-06	-12.4	-5.3	1.4e-07	0.28	0.07	0.33	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CDC16	0.03	0.04	lasso	3	0.04	1.3e-05	-12.4	-14.0	1.2e-44	0.90	0.02	0.98	FALSE
76	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PROZ	0.06	0.10	lasso	8	0.10	4.8e-11	6.3	-6.3	2.8e-10	-0.01	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UPF3A	0.19	0.07	enet	15	0.16	4.4e-18	-12.4	-7.2	6.1e-13	0.42	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PROZ	0.10	0.14	blup	39	0.15	4.0e-10	6.3	-5.7	1.3e-08	-0.04	0.01	0.99	FALSE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CDC16	0.11	0.09	blup	49	0.09	1.8e-04	-13.7	-13.8	1.7e-43	0.98	0.02	0.97	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PROZ	0.11	0.03	blup	39	0.09	1.2e-04	6.0	-5.8	7.7e-09	0.04	0.01	0.90	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UPF3A	0.31	0.08	enet	13	0.17	1.1e-07	-12.4	-8.3	8.5e-17	0.54	0.03	0.58	FALSE
82	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CDC16	0.07	0.03	blup	49	0.05	6.3e-03	-14.0	-13.7	1.6e-42	0.93	0.01	0.87	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PROZ	0.08	0.05	lasso	4	0.05	4.0e-03	6.2	-6.1	8.9e-10	-0.04	0.02	0.76	FALSE
84	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UPF3A	0.10	0.09	lasso	1	0.08	3.8e-04	-12.4	-12.4	1.6e-35	0.76	0.02	0.52	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDC16	0.08	0.07	blup	49	0.08	1.2e-08	-10.9	-12.2	4.6e-34	0.90	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	PROZ	0.12	0.19	lasso	5	0.19	1.2e-19	6.3	-6.3	2.2e-10	-0.01	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	UPF3A	0.14	0.06	blup	32	0.10	3.9e-10	-12.4	-11.0	2.6e-28	0.70	0.19	0.81	FALSE
88	The Cancer Genome Atlas	Rectum Adenocarcinoma	UPF3A	0.25	-0.01	blup	32	-0.01	5.1e-01	-12.4	-8.8	1.2e-18	0.51	0.01	0.26	FALSE
89	The Cancer Genome Atlas	Soft Tissue Sarcoma	PROZ	0.04	0.06	lasso	1	0.05	5.1e-04	6.3	-6.3	3.3e-10	-0.01	0.01	0.88	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	PROZ	0.10	0.08	blup	38	0.08	3.5e-06	6.3	-6.8	1.2e-11	0.02	0.01	0.99	TRUE
91	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PROZ	0.16	0.12	blup	39	0.10	2.3e-04	6.4	-5.6	1.8e-08	0.01	0.01	0.90	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	CDC16	0.06	0.09	lasso	3	0.09	3.3e-09	-14.0	-14.2	4.7e-46	0.98	0.01	0.99	TRUE
93	The Cancer Genome Atlas	Thyroid Carcinoma	PROZ	0.03	0.03	lasso	1	0.02	1.9e-03	6.4	-6.4	2.0e-10	-0.01	0.01	0.92	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	UPF3A	0.14	0.11	enet	9	0.15	1.7e-14	-12.4	-11.9	1.0e-32	0.77	0.07	0.93	FALSE