Best TWAS P=6.71e-12 · Best GWAS P=5.01e-15 conditioned to 5.05e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | AC004453.8 | 0.54 | 0.13 | lasso | 7 | 0.16 | 1.8e-04 | -2.8 | -6.3 | 2.5e-10 | 0.61 | 0.03 | 0.49 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | ZMIZ2 | 0.12 | 0.09 | lasso | 4 | 0.06 | 2.3e-05 | -5.8 | -5.3 | 1.4e-07 | 0.66 | 0.10 | 0.88 | FALSE |
| 3 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPIA | 0.05 | 0.02 | enet | 5 | 0.03 | 7.7e-05 | -7.7 | -6.9 | 6.7e-12 | 0.75 | 0.00 | 0.91 | TRUE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | ZMIZ2 | 0.06 | 0.03 | blup | 35 | 0.03 | 3.8e-04 | 5.1 | 5.3 | 1.1e-07 | -0.81 | 0.04 | 0.92 | FALSE |