Best TWAS P=3.85e-11 · Best GWAS P=8.84e-10 conditioned to 0.0102
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB7 | 0.08 | 0.04 | lasso | 6 | 0.04 | 3.4e-04 | -6.1 | 5.7 | 1.4e-08 | -0.92 | 0.02 | 0.97 | FALSE |
| 2 | GTEx | Artery Aorta | PSMB7 | 0.15 | 0.03 | enet | 16 | 0.05 | 1.4e-03 | 5.2 | 5.4 | 6.6e-08 | -0.56 | 0.08 | 0.62 | FALSE |
| 3 | GTEx | Colon Sigmoid | PSMB7 | 0.15 | 0.10 | lasso | 3 | 0.09 | 3.3e-04 | -6.1 | 5.9 | 3.9e-09 | -0.88 | 0.02 | 0.96 | FALSE |
| 4 | GTEx | Thyroid | NEK6 | 0.20 | 0.21 | lasso | 4 | 0.20 | 1.3e-15 | -5.9 | 6.2 | 6.5e-10 | -0.81 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Thyroid | PSMB7 | 0.06 | 0.04 | lasso | 2 | 0.06 | 4.1e-05 | -5.1 | 5.7 | 1.4e-08 | -0.92 | 0.04 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK6 | 0.04 | 0.02 | blup | 87 | 0.02 | 2.5e-05 | 5.8 | 5.8 | 6.8e-09 | -0.44 | 0.02 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK6 | 0.06 | 0.01 | blup | 87 | 0.04 | 1.0e-04 | 5.8 | 6.6 | 3.9e-11 | -0.62 | 0.01 | 0.96 | TRUE |