Best TWAS P=1.89e-14 · Best GWAS P=3.41e-58 conditioned to 6.32e-60
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TMEM176A | 0.07 | 0.04 | lasso | 8 | 0.03 | 7.0e-05 | 6.40 | 6.8 | 9.6e-12 | 0.06 | 0.64 | 0.08 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | NUB1 | 0.17 | 0.09 | lasso | 4 | 0.12 | 8.9e-10 | 5.03 | 5.2 | 1.6e-07 | -0.06 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | NUB1 | 0.30 | 0.23 | lasso | 4 | 0.23 | 7.9e-13 | -4.30 | 5.4 | 5.4e-08 | -0.07 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Coronary | RP11-148K1.12 | 0.31 | -0.01 | enet | 16 | 0.00 | 2.2e-01 | 6.04 | -7.2 | 8.8e-13 | -0.02 | 0.02 | 0.78 | TRUE |
| 5 | GTEx | Brain Cerebellar Hemisphere | KCNH2 | 0.34 | 0.09 | lasso | 5 | 0.12 | 5.0e-04 | 4.36 | -5.4 | 5.9e-08 | 0.01 | 0.12 | 0.07 | FALSE |
| 6 | GTEx | Brain Cerebellum | KCNH2 | 0.35 | 0.20 | enet | 24 | 0.28 | 4.8e-09 | -8.83 | -6.9 | 5.6e-12 | -0.01 | 0.87 | 0.06 | TRUE |
| 7 | GTEx | Cells Transformed fibroblasts | CHPF2 | 0.12 | 0.03 | enet | 10 | 0.00 | 1.8e-01 | -4.72 | 5.6 | 2.7e-08 | 0.01 | 0.28 | 0.04 | TRUE |
| 8 | GTEx | Colon Sigmoid | RP4-800G7.2 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.9e-03 | 3.44 | 5.9 | 4.5e-09 | 0.06 | 0.32 | 0.05 | TRUE |
| 9 | GTEx | Heart Atrial Appendage | TMEM176B | 0.37 | 0.06 | enet | 15 | 0.23 | 1.1e-10 | -0.05 | -5.2 | 1.6e-07 | 0.05 | 0.58 | 0.05 | FALSE |
| 10 | GTEx | Heart Left Ventricle | FASTK | 0.26 | 0.04 | enet | 8 | 0.04 | 3.0e-03 | 3.51 | 5.2 | 2.0e-07 | 0.04 | 0.12 | 0.04 | FALSE |
| 11 | GTEx | Lung | CHPF2 | 0.11 | 0.00 | lasso | 1 | 0.00 | 2.0e-01 | -5.30 | 5.3 | 1.1e-07 | 0.01 | 0.36 | 0.02 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | NUB1 | 0.20 | 0.12 | enet | 26 | 0.13 | 5.9e-11 | -3.88 | 6.5 | 1.0e-10 | -0.04 | 1.00 | 0.00 | TRUE |
| 13 | GTEx | Spleen | ZNF783 | 0.32 | -0.01 | enet | 34 | 0.05 | 2.4e-02 | 3.35 | 5.2 | 2.5e-07 | 0.13 | 0.09 | 0.05 | FALSE |
| 14 | GTEx | Uterus | GIMAP4 | 0.32 | -0.01 | enet | 42 | 0.02 | 1.4e-01 | 2.40 | -6.4 | 1.3e-10 | 0.02 | 0.06 | 0.06 | FALSE |
| 15 | METSIM | Adipose | AOC1 | 0.17 | 0.08 | enet | 26 | 0.11 | 3.2e-16 | 5.68 | 7.7 | 1.9e-14 | -0.02 | 0.52 | 0.48 | TRUE |
| 16 | ROSMAP | Brain Pre-frontal Cortex | TMEM176A | 0.25 | 0.17 | enet | 19 | 0.20 | 1.5e-25 | 4.71 | 6.7 | 2.1e-11 | 0.04 | 1.00 | 0.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | TMUB1 | 0.05 | 0.01 | bslmm | 511 | 0.01 | 7.2e-03 | 4.26 | -5.3 | 1.1e-07 | -0.02 | 0.09 | 0.04 | FALSE |
| 18 | YFS | Blood | FASTK | 0.04 | 0.01 | blup | 515 | 0.02 | 1.9e-07 | 3.51 | 6.7 | 2.1e-11 | 0.01 | 1.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM176A | 0.06 | 0.01 | blup | 60 | 0.03 | 1.0e-03 | 5.92 | 6.8 | 1.0e-11 | 0.01 | 0.06 | 0.17 | FALSE |
| 20 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM176A | 0.04 | 0.01 | blup | 60 | 0.04 | 4.0e-08 | 5.92 | 5.8 | 6.5e-09 | 0.04 | 0.12 | 0.16 | FALSE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM176A | 0.22 | 0.01 | blup | 60 | 0.14 | 1.7e-15 | 1.32 | 5.2 | 1.5e-07 | -0.03 | 0.92 | 0.03 | FALSE |
| 22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM176B | 0.21 | 0.11 | blup | 72 | 0.15 | 2.4e-16 | 1.32 | 5.4 | 7.3e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ABP1 | 0.16 | 0.19 | lasso | 4 | 0.20 | 9.3e-22 | -7.00 | 6.8 | 1.3e-11 | -0.02 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CHPF2 | 0.07 | 0.03 | blup | 51 | 0.05 | 8.6e-07 | 4.20 | 5.5 | 4.6e-08 | 0.01 | 0.08 | 0.86 | FALSE |
| 25 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM176A | 0.19 | 0.05 | lasso | 6 | 0.13 | 2.6e-14 | -7.00 | 7.0 | 2.0e-12 | -0.04 | 0.06 | 0.94 | FALSE |
| 26 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TMEM176A | 0.17 | 0.05 | blup | 60 | 0.07 | 5.1e-05 | -1.79 | 5.4 | 7.1e-08 | -0.04 | 0.36 | 0.26 | FALSE |
| 27 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABP1 | 0.26 | 0.20 | enet | 10 | 0.17 | 1.4e-08 | -6.53 | -7.0 | 1.9e-12 | 0.03 | 0.97 | 0.03 | FALSE |
| 28 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM176B | 0.06 | 0.01 | blup | 72 | 0.03 | 7.7e-05 | 1.31 | 5.2 | 1.9e-07 | 0.03 | 0.08 | 0.16 | FALSE |
| 29 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ATG9B | 0.08 | 0.03 | lasso | 3 | 0.03 | 2.5e-03 | -0.58 | -5.6 | 1.7e-08 | 0.06 | 0.01 | 0.86 | FALSE |
| 30 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHPF2 | 0.06 | 0.02 | lasso | 5 | 0.02 | 1.3e-03 | -5.30 | 5.5 | 3.4e-08 | 0.00 | 0.01 | 0.97 | FALSE |
| 31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM176A | 0.15 | 0.01 | blup | 60 | 0.04 | 6.1e-05 | 8.74 | 5.5 | 2.9e-08 | 0.02 | 0.06 | 0.69 | FALSE |
| 32 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM176A | 0.15 | 0.00 | lasso | 10 | 0.02 | 5.7e-02 | 8.74 | 7.6 | 3.7e-14 | 0.02 | 0.01 | 0.31 | FALSE |
| 33 | The Cancer Genome Atlas | Thyroid Carcinoma | CHPF2 | 0.03 | 0.03 | blup | 51 | 0.03 | 1.2e-03 | -4.67 | 5.1 | 2.9e-07 | 0.01 | 0.02 | 0.87 | FALSE |
| 34 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM176A | 0.32 | 0.09 | blup | 60 | 0.11 | 6.7e-11 | -0.05 | 5.7 | 1.3e-08 | 0.00 | 1.00 | 0.00 | FALSE |
| 35 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | ZNF786 | 0.20 | 0.06 | blup | 29 | 0.09 | 1.4e-03 | 3.35 | -5.2 | 2.2e-07 | 0.02 | 0.05 | 0.08 | FALSE |