[Hub]/) : Traits : Trunk fat mass :

chr11:64,954,053-68,514,265

Best TWAS P=7.96e-17 · Best GWAS P=1.04e-16 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FIBP 0.08 0.11 enet 20 0.12 8.1e-14 4.0 5.9 3.7e-09 -0.06 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex PTPRCAP 0.05 0.07 enet 12 0.07 6.0e-09 -5.3 5.5 4.5e-08 -0.16 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous RAD9A 0.43 0.22 lasso 6 0.23 7.1e-19 -8.3 -8.2 3.0e-16 0.97 0.00 1.00 FALSE
4 GTEx Adipose Subcutaneous AP003419.16 0.05 0.08 lasso 1 0.07 1.7e-06 -5.4 5.4 6.3e-08 -0.15 0.86 0.00 FALSE
5 GTEx Adipose Visceral Omentum GSTP1 0.11 0.12 lasso 7 0.10 6.7e-06 -5.7 5.3 1.1e-07 -0.12 0.95 0.00 FALSE
6 GTEx Adipose Visceral Omentum RPS6KB2 0.08 0.03 lasso 8 0.04 2.9e-03 -5.4 5.8 5.1e-09 -0.15 0.52 0.04 FALSE
7 GTEx Adipose Visceral Omentum PTPRCAP 0.10 0.08 enet 7 0.06 4.8e-04 -5.4 5.6 2.6e-08 -0.15 0.66 0.02 FALSE
8 GTEx Adipose Visceral Omentum AP003419.16 0.09 0.05 enet 8 0.04 4.6e-03 -5.4 5.7 1.0e-08 -0.17 0.35 0.09 FALSE
9 GTEx Artery Aorta GSTP1 0.10 0.07 enet 14 0.10 5.4e-06 -5.9 5.7 1.3e-08 -0.15 0.72 0.03 FALSE
10 GTEx Artery Aorta PTPRCAP 0.11 0.07 enet 9 0.08 3.6e-05 -5.4 5.2 2.0e-07 -0.13 0.76 0.01 FALSE
11 GTEx Artery Aorta AP003419.16 0.16 0.10 lasso 3 0.10 4.5e-06 -5.4 5.4 7.1e-08 -0.15 0.87 0.00 FALSE
12 GTEx Artery Tibial GSTP1 0.09 0.07 enet 8 0.11 7.4e-09 -5.7 5.3 1.1e-07 -0.13 1.00 0.00 FALSE
13 GTEx Artery Tibial RAD9A 0.39 0.26 lasso 2 0.24 3.5e-19 -8.3 -8.3 1.2e-16 1.00 0.00 1.00 FALSE
14 GTEx Artery Tibial RPS6KB2 0.10 0.10 lasso 1 0.10 5.9e-08 -5.4 5.4 5.2e-08 -0.15 0.99 0.00 FALSE
15 GTEx Artery Tibial PTPRCAP 0.18 0.25 lasso 7 0.24 5.9e-19 -5.3 5.3 9.0e-08 -0.16 1.00 0.00 FALSE
16 GTEx Artery Tibial AP003419.16 0.11 0.13 lasso 2 0.12 2.2e-09 -5.4 5.5 4.3e-08 -0.15 1.00 0.00 FALSE
17 GTEx Brain Caudate basal ganglia GSTP1 0.16 0.14 lasso 3 0.16 2.8e-05 4.6 5.6 2.6e-08 -0.14 0.14 0.32 FALSE
18 GTEx Brain Caudate basal ganglia PTPRCAP 0.23 0.19 lasso 4 0.21 1.0e-06 -5.4 5.8 9.0e-09 -0.18 0.77 0.04 FALSE
19 GTEx Brain Cerebellar Hemisphere GSTP1 0.25 0.15 enet 16 0.20 8.7e-06 -4.7 6.5 6.7e-11 -0.33 0.53 0.34 FALSE
20 GTEx Brain Cerebellar Hemisphere PTPRCAP 0.39 0.43 lasso 8 0.47 7.7e-14 -5.7 5.7 1.4e-08 -0.16 1.00 0.00 FALSE
21 GTEx Brain Cerebellar Hemisphere AP003419.16 0.20 0.01 lasso 4 0.05 1.7e-02 -5.9 6.0 2.5e-09 -0.20 0.04 0.17 FALSE
22 GTEx Brain Cerebellum NDUFV1 0.19 0.01 enet 29 0.05 1.7e-02 4.5 -6.3 2.8e-10 0.30 0.07 0.06 FALSE
23 GTEx Brain Cerebellum PTPRCAP 0.39 0.48 lasso 7 0.46 3.8e-15 -5.4 5.6 2.0e-08 -0.17 1.00 0.00 FALSE
24 GTEx Brain Frontal Cortex BA9 GSTP1 0.28 0.19 lasso 5 0.16 3.8e-05 -5.7 5.5 3.3e-08 -0.13 0.51 0.03 FALSE
25 GTEx Brain Frontal Cortex BA9 PTPRCAP 0.21 0.11 enet 15 0.15 9.6e-05 -5.4 5.8 5.8e-09 -0.16 0.55 0.03 FALSE
26 GTEx Brain Hippocampus PTPRCAP 0.16 0.13 lasso 4 0.18 6.2e-05 -5.7 5.6 1.8e-08 -0.15 0.15 0.05 FALSE
27 GTEx Brain Hypothalamus GSTP1 0.29 0.28 lasso 3 0.26 9.3e-07 -5.9 5.8 6.9e-09 -0.12 0.52 0.05 FALSE
28 GTEx Brain Hypothalamus PTPRCAP 0.17 0.21 lasso 4 0.19 3.1e-05 -5.4 5.6 2.2e-08 -0.16 0.31 0.09 FALSE
29 GTEx Brain Nucleus accumbens basal ganglia GSTP1 0.23 0.11 lasso 5 0.14 1.8e-04 -5.7 5.9 4.2e-09 -0.14 0.48 0.04 FALSE
30 GTEx Brain Nucleus accumbens basal ganglia NUDT8 0.15 0.19 lasso 8 0.15 7.3e-05 -5.2 -5.3 1.4e-07 0.19 0.16 0.05 FALSE
31 GTEx Brain Nucleus accumbens basal ganglia PTPRCAP 0.35 0.36 lasso 7 0.38 2.7e-11 -5.4 5.5 4.3e-08 -0.17 0.99 0.00 FALSE
32 GTEx Brain Putamen basal ganglia PTPRCAP 0.24 0.26 lasso 4 0.22 6.2e-06 -5.4 5.4 5.6e-08 -0.16 0.62 0.02 FALSE
33 GTEx Breast Mammary Tissue GSTP1 0.23 0.14 lasso 5 0.13 4.7e-07 -5.5 5.2 1.5e-07 -0.11 0.97 0.00 FALSE
34 GTEx Breast Mammary Tissue PTPRCAP 0.18 0.26 lasso 3 0.24 2.0e-12 -5.5 5.6 2.7e-08 -0.16 1.00 0.00 FALSE
35 GTEx Breast Mammary Tissue AP003419.16 0.19 0.06 lasso 5 0.05 2.3e-03 -5.9 5.7 1.0e-08 -0.16 0.16 0.18 FALSE
36 GTEx Breast Mammary Tissue (Male) GSTP1 0.11 -0.01 lasso 2 -0.01 7.7e-01 -5.1 6.7 2.8e-11 -0.40 0.02 0.42 FALSE
37 GTEx Breast Mammary Tissue (Male) NDUFV1 0.11 0.05 enet 8 0.03 5.6e-02 4.6 -5.5 3.7e-08 0.13 0.07 0.06 FALSE
38 GTEx Breast Mammary Tissue (Female) GSTP1 0.26 0.10 lasso 1 0.09 1.2e-03 -5.5 5.5 4.7e-08 -0.12 0.09 0.05 FALSE
39 GTEx Cells Transformed fibroblasts RAD9A 0.24 0.16 lasso 3 0.16 3.6e-12 -8.3 -6.3 2.8e-10 0.92 0.00 1.00 TRUE
40 GTEx Cells Transformed fibroblasts RPS6KB2 0.19 0.28 lasso 3 0.27 1.7e-20 -5.4 5.5 3.2e-08 -0.16 1.00 0.00 FALSE
41 GTEx Cells Transformed fibroblasts AP003419.16 0.21 0.22 lasso 6 0.21 1.6e-15 -5.4 5.7 1.0e-08 -0.18 1.00 0.00 FALSE
42 GTEx Colon Sigmoid GSTP1 0.19 0.21 enet 11 0.19 2.7e-07 -5.7 5.3 1.1e-07 -0.12 0.97 0.00 FALSE
43 GTEx Colon Transverse RAD9A 0.40 0.16 lasso 8 0.16 7.2e-08 -8.3 -6.0 2.3e-09 0.88 0.00 1.00 FALSE
44 GTEx Colon Transverse PTPRCAP 0.14 0.06 lasso 7 0.07 3.8e-04 -5.5 5.3 1.2e-07 -0.16 0.73 0.01 FALSE
45 GTEx Esophagus Gastroesophageal Junction AP003419.16 0.25 0.18 lasso 16 0.18 6.7e-07 -5.4 5.2 2.6e-07 -0.14 0.89 0.01 FALSE
46 GTEx Esophagus Mucosa RPS6KB2 0.12 0.09 lasso 3 0.11 1.1e-07 -5.4 5.8 7.8e-09 -0.20 0.97 0.00 FALSE
47 GTEx Esophagus Mucosa AP003419.16 0.18 0.15 lasso 3 0.18 7.8e-12 -5.4 5.7 1.1e-08 -0.18 1.00 0.00 FALSE
48 GTEx Esophagus Muscularis GSTP1 0.16 0.18 lasso 3 0.16 9.1e-10 -5.5 5.7 1.4e-08 -0.14 1.00 0.00 FALSE
49 GTEx Esophagus Muscularis TCIRG1 0.10 0.09 lasso 2 0.06 8.7e-05 -4.8 5.5 4.3e-08 -0.43 0.15 0.30 FALSE
50 GTEx Esophagus Muscularis RAD9A 0.25 0.26 lasso 2 0.26 6.2e-16 -8.3 -8.0 1.5e-15 0.99 0.00 1.00 FALSE
51 GTEx Esophagus Muscularis YIF1A 0.11 0.05 enet 11 0.04 2.4e-03 4.3 -5.5 4.8e-08 0.05 0.82 0.16 FALSE
52 GTEx Esophagus Muscularis PTPRCAP 0.21 0.26 lasso 4 0.26 9.2e-16 -5.3 5.4 8.0e-08 -0.16 1.00 0.00 FALSE
53 GTEx Esophagus Muscularis CTD-3074O7.5 0.22 0.02 enet 17 0.09 3.7e-06 -1.7 6.0 1.8e-09 -0.03 0.27 0.50 TRUE
54 GTEx Esophagus Muscularis AP003419.16 0.19 0.17 lasso 3 0.18 7.3e-11 -5.4 5.4 6.9e-08 -0.15 1.00 0.00 FALSE
55 GTEx Heart Atrial Appendage RPS6KB2 0.16 0.09 lasso 9 0.07 3.5e-04 -5.4 5.6 1.9e-08 -0.18 0.53 0.05 TRUE
56 GTEx Heart Atrial Appendage PTPRCAP 0.14 0.11 lasso 10 0.09 5.1e-05 -5.4 6.5 8.4e-11 -0.24 0.67 0.03 FALSE
57 GTEx Heart Atrial Appendage AP003419.16 0.11 0.10 lasso 5 0.12 4.4e-06 -5.4 5.5 4.9e-08 -0.15 0.80 0.01 FALSE
58 GTEx Heart Left Ventricle RPS6KB2 0.14 0.14 lasso 4 0.15 2.6e-08 -5.4 5.4 6.8e-08 -0.16 0.99 0.00 FALSE
59 GTEx Heart Left Ventricle AP003419.16 0.19 0.16 lasso 5 0.16 6.8e-09 -5.4 5.3 1.0e-07 -0.15 1.00 0.00 FALSE
60 GTEx Liver CDK2AP2 0.30 -0.01 lasso 7 -0.01 4.9e-01 -4.1 -6.6 3.5e-11 0.46 0.02 0.47 TRUE
61 GTEx Muscle Skeletal GSTP1 0.07 0.08 lasso 9 0.07 1.0e-07 -5.5 5.6 1.7e-08 -0.15 0.99 0.00 FALSE
62 GTEx Muscle Skeletal RAD9A 0.12 0.02 lasso 4 0.03 4.2e-04 -8.3 -5.6 2.6e-08 0.83 0.00 0.99 TRUE
63 GTEx Muscle Skeletal RPS6KB2 0.17 0.20 lasso 3 0.20 8.3e-19 -5.4 5.3 8.7e-08 -0.15 1.00 0.00 FALSE
64 GTEx Muscle Skeletal PTPRCAP 0.09 0.08 lasso 6 0.09 2.6e-09 -5.4 5.4 6.6e-08 -0.16 1.00 0.00 FALSE
65 GTEx Muscle Skeletal AP003419.16 0.19 0.21 lasso 2 0.20 1.4e-19 -5.4 5.5 4.9e-08 -0.15 1.00 0.00 FALSE
66 GTEx Nerve Tibial NDUFV1 0.19 0.26 enet 18 0.26 1.7e-18 -4.1 -5.2 2.6e-07 0.22 1.00 0.00 FALSE
67 GTEx Nerve Tibial RAD9A 0.53 0.24 lasso 10 0.23 5.6e-16 -8.3 -8.3 8.0e-17 0.99 0.00 1.00 TRUE
68 GTEx Nerve Tibial PTPRCAP 0.33 0.38 enet 14 0.47 2.1e-37 -5.3 5.5 5.1e-08 -0.15 1.00 0.00 FALSE
69 GTEx Nerve Tibial DOC2GP 0.23 0.11 enet 12 0.12 6.4e-09 -4.5 5.1 2.7e-07 -0.24 0.97 0.00 FALSE
70 GTEx Ovary PTPRCAP 0.35 0.28 enet 13 0.26 5.3e-07 -5.4 5.5 3.6e-08 -0.16 0.78 0.01 FALSE
71 GTEx Pancreas TMEM134 0.17 0.04 enet 20 0.03 1.5e-02 -4.5 5.5 4.2e-08 -0.16 0.06 0.05 FALSE
72 GTEx Pancreas AP003419.16 0.11 0.05 enet 14 0.07 8.4e-04 -5.4 5.9 3.6e-09 -0.18 0.53 0.03 FALSE
73 GTEx Pituitary PTPRCAP 0.24 0.33 lasso 6 0.26 4.0e-07 -5.4 5.6 2.3e-08 -0.16 0.90 0.01 FALSE
74 GTEx Skin Not Sun Exposed Suprapubic RPS6KB2 0.11 0.00 lasso 6 0.00 2.3e-01 -5.3 5.7 1.4e-08 -0.25 0.04 0.05 FALSE
75 GTEx Skin Not Sun Exposed Suprapubic PTPRCAP 0.22 0.14 enet 19 0.15 1.8e-08 -5.3 5.9 3.1e-09 -0.18 1.00 0.00 FALSE
76 GTEx Skin Not Sun Exposed Suprapubic AP003419.16 0.15 0.08 lasso 5 0.08 6.2e-05 -5.7 6.3 2.6e-10 -0.21 0.50 0.02 FALSE
77 GTEx Skin Sun Exposed Lower leg NDUFV1 0.11 0.11 lasso 4 0.11 2.5e-09 -5.1 -5.3 1.5e-07 0.18 1.00 0.00 FALSE
78 GTEx Skin Sun Exposed Lower leg AP003419.16 0.14 0.14 lasso 6 0.13 9.4e-11 -5.4 5.3 8.9e-08 -0.14 1.00 0.00 FALSE
79 GTEx Stomach AP003419.16 0.12 0.11 lasso 4 0.08 1.4e-04 -5.4 5.5 3.1e-08 -0.15 0.41 0.03 FALSE
80 GTEx Testis GSTP1 0.09 0.11 lasso 2 0.08 3.1e-04 -5.5 5.5 4.7e-08 -0.12 0.51 0.05 FALSE
81 GTEx Testis AIP 0.11 0.14 lasso 2 0.11 1.5e-05 -5.5 5.6 2.5e-08 -0.18 0.85 0.02 FALSE
82 GTEx Testis RAD9A 0.72 0.50 lasso 4 0.49 1.1e-24 -8.3 -8.3 1.5e-16 1.00 0.00 1.00 FALSE
83 GTEx Testis RPS6KB2 0.20 0.16 lasso 11 0.16 8.3e-08 -5.4 5.7 1.4e-08 -0.17 1.00 0.00 FALSE
84 GTEx Testis AP003419.16 0.22 0.18 lasso 8 0.18 1.3e-08 -5.4 5.5 3.3e-08 -0.16 1.00 0.00 FALSE
85 GTEx Thyroid PACS1 0.09 0.04 enet 16 0.09 2.8e-07 -7.8 -5.2 1.7e-07 0.11 0.01 0.98 FALSE
86 GTEx Thyroid PTPRCAP 0.17 0.19 lasso 4 0.21 1.1e-15 -5.3 5.4 8.3e-08 -0.16 1.00 0.00 FALSE
87 GTEx Uterus PACS1 0.21 -0.01 enet 21 0.05 3.6e-02 4.1 -6.0 1.5e-09 0.15 0.07 0.28 TRUE
88 GTEx Uterus PTPRCAP 0.28 0.15 lasso 5 0.15 5.5e-04 -5.9 6.0 1.9e-09 -0.17 0.14 0.07 FALSE
89 GTEx Vagina PTPRCAP 0.33 0.05 enet 8 0.06 2.0e-02 -5.4 5.8 6.2e-09 -0.16 0.09 0.06 FALSE
90 METSIM Adipose GSTP1 0.05 0.05 lasso 6 0.04 9.3e-07 -5.9 5.9 4.3e-09 -0.13 1.00 0.00 FALSE
91 METSIM Adipose PTPRCAP 0.03 0.02 lasso 4 0.02 1.7e-04 -5.9 6.0 2.8e-09 -0.17 0.74 0.01 FALSE
92 ROSMAP Brain Pre-frontal Cortex GSTP1 0.25 0.38 lasso 7 0.42 6.1e-58 -5.7 5.4 6.1e-08 -0.11 1.00 0.00 FALSE
93 ROSMAP Brain Pre-frontal Cortex NDUFV1 0.08 0.09 enet 17 0.09 5.3e-12 -4.1 -5.3 1.1e-07 0.21 1.00 0.00 FALSE
94 ROSMAP Brain Pre-frontal Cortex CDK2AP2 0.03 0.02 enet 11 0.03 1.6e-04 -5.2 7.6 2.1e-14 -0.48 0.27 0.60 TRUE
95 ROSMAP Brain Pre-frontal Cortex RAD9A 0.34 0.17 enet 21 0.20 1.1e-25 -8.3 -6.5 6.5e-11 0.89 0.00 1.00 FALSE
96 ROSMAP Brain Pre-frontal Cortex RPS6KB2 0.24 0.37 lasso 5 0.37 7.2e-50 -5.3 5.3 1.1e-07 -0.15 1.00 0.00 FALSE
97 ROSMAP Brain Pre-frontal Cortex PTPRCAP 0.31 0.47 enet 14 0.47 2.7e-68 -5.4 5.4 6.2e-08 -0.15 1.00 0.00 FALSE
98 YFS Blood RAD9A 0.08 0.02 lasso 7 0.04 5.4e-12 -8.3 -5.2 1.8e-07 0.78 0.00 1.00 FALSE
99 YFS Blood RPS6KB2 0.04 0.05 lasso 7 0.05 6.7e-17 -5.3 5.3 1.0e-07 -0.15 1.00 0.00 FALSE
100 The Cancer Genome Atlas Breast Invasive Carcinoma PACS1 0.02 0.02 blup 77 0.02 8.5e-05 4.7 -5.3 1.3e-07 0.09 0.50 0.12 FALSE
101 The Cancer Genome Atlas Breast Invasive Carcinoma RPS6KB2 0.05 0.06 lasso 3 0.06 1.1e-12 -5.7 5.7 1.3e-08 -0.16 0.01 0.99 TRUE
102 The Cancer Genome Atlas Colon Adenocarcinoma RPS6KB2 0.11 0.12 lasso 6 0.10 1.2e-06 -5.4 5.4 7.9e-08 -0.16 0.03 0.97 FALSE
103 The Cancer Genome Atlas Glioblastoma Multiforme CTSW 0.16 0.18 enet 16 0.19 2.3e-06 4.3 -5.2 2.3e-07 0.09 0.40 0.16 FALSE
104 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CNIH2 0.03 0.00 enet 4 0.02 6.4e-03 -4.9 5.8 6.8e-09 -0.22 0.06 0.12 TRUE
105 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS6KB2 0.09 0.16 enet 9 0.15 2.1e-16 -5.4 5.4 8.2e-08 -0.16 0.04 0.96 FALSE
106 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma GSTP1 0.04 0.05 lasso 5 0.04 1.7e-03 -5.7 5.8 7.7e-09 -0.12 0.01 0.94 FALSE
107 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PTPRCAP 0.05 0.04 enet 3 0.03 1.2e-02 -5.9 6.1 1.3e-09 -0.20 0.00 0.90 FALSE
108 The Cancer Genome Atlas Brain Lower Grade Glioma GSTP1 0.11 0.08 enet 5 0.07 7.2e-09 -5.7 5.5 3.1e-08 -0.11 0.01 0.99 FALSE
109 The Cancer Genome Atlas Lung Adenocarcinoma RPS6KB2 0.05 0.07 lasso 4 0.06 6.2e-08 -5.7 5.7 1.2e-08 -0.17 0.01 0.99 FALSE
110 The Cancer Genome Atlas Lung Adenocarcinoma SNX32 0.14 0.09 blup 60 0.13 8.8e-15 5.1 5.2 2.2e-07 -0.07 0.87 0.13 FALSE
111 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RPS6KB2 0.05 0.05 lasso 6 0.04 1.2e-05 -5.4 5.4 5.7e-08 -0.17 0.03 0.97 FALSE
112 The Cancer Genome Atlas Prostate Adenocarcinoma PTPRCAP 0.08 0.10 lasso 2 0.10 7.8e-11 -5.3 5.3 9.5e-08 -0.16 0.03 0.97 FALSE
113 The Cancer Genome Atlas Prostate Adenocarcinoma RPS6KB2 0.09 0.13 lasso 6 0.13 7.1e-14 -5.4 5.4 6.6e-08 -0.14 0.03 0.97 FALSE
114 The Cancer Genome Atlas Soft Tissue Sarcoma RPS6KB2 0.05 0.04 lasso 2 0.04 2.1e-03 -5.4 5.4 6.3e-08 -0.15 0.02 0.90 FALSE
115 The Cancer Genome Atlas Stomach Adenocarcinoma RPS6KB2 0.10 0.11 lasso 4 0.10 8.6e-08 -5.3 5.4 8.4e-08 -0.16 0.04 0.96 FALSE
116 The Cancer Genome Atlas Stomach Adenocarcinoma SNX32 0.12 0.13 blup 60 0.13 1.2e-09 4.0 5.6 2.3e-08 -0.08 0.97 0.02 TRUE
117 The Cancer Genome Atlas Testicular Germ Cell Tumors RPS6KB2 0.12 0.06 blup 35 0.05 5.4e-03 -5.7 6.5 7.7e-11 -0.16 0.01 0.79 TRUE
118 The Cancer Genome Atlas Testicular Germ Cell Tumors TBC1D10C 0.12 0.05 lasso 5 0.03 3.0e-02 -5.4 5.4 8.1e-08 -0.16 0.02 0.68 FALSE
119 The Cancer Genome Atlas Thyroid Carcinoma NDUFV1 0.03 0.00 blup 43 0.01 6.7e-02 -5.1 -5.7 1.5e-08 0.18 0.01 0.88 FALSE