Best TWAS P=9.7e-14 · Best GWAS P=7.31e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IPO9 | 0.21 | 0.09 | enet | 36 | 0.13 | 2.3e-15 | 7.5 | 6.1 | 1.1e-09 | -0.32 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | SHISA4 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.5e-03 | 5.7 | 6.0 | 2.2e-09 | -0.57 | 0.18 | 0.39 | FALSE |
| 3 | GTEx | Esophagus Muscularis | LMOD1 | 0.16 | 0.09 | enet | 9 | 0.08 | 7.8e-06 | -7.8 | 7.2 | 4.7e-13 | -0.98 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-307B6.3 | 0.20 | 0.12 | lasso | 3 | 0.12 | 5.6e-08 | -7.8 | 7.1 | 1.3e-12 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | METSIM | Adipose | LMOD1 | 0.09 | 0.07 | bslmm | 496 | 0.07 | 4.8e-10 | -7.6 | 7.4 | 9.7e-14 | -0.96 | 0.02 | 0.98 | TRUE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LMOD1 | 0.07 | 0.06 | blup | 59 | 0.03 | 2.1e-02 | -7.6 | 6.0 | 1.5e-09 | -0.90 | 0.01 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMOD1 | 0.04 | 0.07 | enet | 6 | 0.05 | 9.4e-07 | 5.8 | 6.5 | 9.2e-11 | -0.75 | 0.28 | 0.72 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | LMOD1 | 0.04 | 0.01 | blup | 59 | 0.01 | 5.7e-02 | -7.5 | 7.1 | 1.5e-12 | -0.83 | 0.01 | 0.79 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LMOD1 | 0.08 | -0.01 | blup | 59 | 0.01 | 1.3e-01 | -0.1 | 5.5 | 5.0e-08 | -0.78 | 0.01 | 0.39 | FALSE |