Best TWAS P=7.68e-12 · Best GWAS P=7.57e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | MED19 | 0.11 | 0.04 | enet | 26 | 0.10 | 7.5e-06 | 6.3 | -5.5 | 4.0e-08 | -0.76 | 0.02 | 0.93 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | 6.3 | -6.3 | 3.9e-10 | -0.97 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | 6.4 | -6.4 | 1.3e-10 | -0.99 | 0.02 | 0.89 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | 6.4 | 6.3 | 2.8e-10 | 0.91 | 0.04 | 0.95 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | MED19 | 0.15 | 0.11 | lasso | 7 | 0.09 | 1.3e-07 | 6.5 | -6.3 | 2.5e-10 | -0.98 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Stomach | MED19 | 0.10 | 0.04 | lasso | 7 | 0.09 | 6.8e-05 | 6.4 | -5.9 | 3.7e-09 | -0.90 | 0.02 | 0.92 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | ZDHHC5 | 0.05 | 0.02 | blup | 401 | 0.03 | 2.0e-04 | 6.5 | -5.8 | 6.5e-09 | -0.78 | 0.01 | 0.96 | FALSE |
| 8 | YFS | Blood | ZDHHC5 | 0.06 | 0.07 | enet | 20 | 0.07 | 1.2e-22 | 6.3 | 6.8 | 7.7e-12 | 0.96 | 0.01 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MED19 | 0.05 | 0.03 | enet | 7 | 0.05 | 1.3e-10 | 6.4 | -5.3 | 9.5e-08 | -0.84 | 0.01 | 0.99 | FALSE |
| 10 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMX2 | 0.07 | 0.06 | lasso | 1 | 0.05 | 5.0e-04 | 6.5 | 6.5 | 8.6e-11 | 0.99 | 0.00 | 0.92 | FALSE |
| 11 | The Cancer Genome Atlas | Esophageal Carcinoma | MED19 | 0.10 | 0.06 | lasso | 4 | 0.02 | 5.4e-02 | 6.5 | -6.5 | 7.5e-11 | -1.00 | 0.00 | 0.85 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MED19 | 0.03 | 0.01 | lasso | 2 | 0.02 | 1.9e-03 | 6.4 | -5.4 | 6.4e-08 | -0.81 | 0.00 | 0.68 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | MED19 | 0.05 | 0.02 | blup | 26 | 0.03 | 6.0e-05 | 6.5 | -5.5 | 2.9e-08 | -0.85 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | 6.3 | -6.3 | 3.9e-10 | -0.97 | 0.00 | 0.85 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMX2 | 0.03 | 0.02 | blup | 29 | 0.02 | 3.7e-03 | -3.9 | 5.1 | 2.9e-07 | 0.74 | 0.06 | 0.59 | FALSE |