[Hub]/) : Traits : Irritability : ← →

chr20:32,254,831-34,109,427

Best TWAS P=2.11e-13 · Best GWAS P=7.08e-12 conditioned to 0.826

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	NCOA6	0.11	0.10	lasso	10	0.10	4.5e-06	6.5	6.6	4.7e-11	0.81	0.12	0.85	FALSE
2	GTEx	Adrenal Gland	NCOA6	0.10	0.08	lasso	14	0.05	7.7e-03	5.6	6.6	5.1e-11	0.91	0.04	0.86	FALSE
3	GTEx	Artery Coronary	NCOA6	0.20	0.15	enet	27	0.24	1.1e-08	-3.1	6.1	1.1e-09	0.79	0.06	0.94	FALSE
4	GTEx	Brain Cerebellum	NCOA6	0.26	0.11	lasso	9	0.22	4.1e-07	6.8	5.9	2.8e-09	0.75	0.06	0.93	FALSE
5	GTEx	Brain Cortex	NCOA6	0.14	0.03	enet	13	0.05	1.6e-02	-3.1	5.9	2.9e-09	0.73	0.06	0.60	FALSE
6	GTEx	Brain Frontal Cortex BA9	NCOA6	0.13	0.00	enet	30	0.06	1.3e-02	-3.1	5.6	1.9e-08	0.68	0.07	0.64	FALSE
7	GTEx	Brain Nucleus accumbens basal ganglia	NCOA6	0.24	0.01	lasso	12	0.08	3.2e-03	-3.1	6.1	8.6e-10	0.68	0.06	0.77	FALSE
8	GTEx	Breast Mammary Tissue	NCOA6	0.12	0.02	enet	35	0.04	4.5e-03	-2.4	6.1	1.1e-09	0.67	0.07	0.82	FALSE
9	GTEx	Cells Transformed fibroblasts	NCOA6	0.09	0.12	enet	25	0.09	1.5e-07	6.8	6.8	1.3e-11	0.91	0.03	0.97	FALSE
10	GTEx	Colon Sigmoid	TP53INP2	0.12	0.09	lasso	3	0.06	2.8e-03	6.8	-7.3	2.1e-13	-0.92	0.04	0.82	TRUE
11	GTEx	Colon Transverse	NCOA6	0.10	0.06	lasso	8	0.04	4.1e-03	6.6	6.7	2.1e-11	0.88	0.04	0.92	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	ITCH	0.11	0.03	lasso	4	0.04	9.9e-03	6.8	6.6	4.8e-11	0.90	0.04	0.90	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	NCOA6	0.24	0.07	lasso	4	0.08	5.9e-04	6.6	6.4	2.1e-10	0.79	0.04	0.90	FALSE
14	GTEx	Esophagus Muscularis	NCOA6	0.14	0.10	enet	22	0.20	2.6e-12	-3.1	5.7	1.1e-08	0.74	0.15	0.85	FALSE
15	GTEx	Nerve Tibial	NCOA6	0.24	0.12	enet	50	0.20	5.2e-14	6.8	6.0	1.7e-09	0.74	0.05	0.95	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	NCOA6	0.13	0.03	enet	12	0.03	1.5e-02	6.6	5.8	5.8e-09	0.70	0.04	0.87	FALSE
17	GTEx	Testis	NCOA6	0.27	0.18	lasso	20	0.26	4.1e-12	6.8	6.0	2.5e-09	0.79	0.04	0.96	FALSE
18	GTEx	Thyroid	TP53INP2	0.09	0.05	lasso	7	0.04	3.7e-04	6.8	-7.0	2.5e-12	-0.93	0.04	0.96	FALSE
19	GTEx	Thyroid	NCOA6	0.16	0.12	enet	29	0.16	2.1e-12	6.6	5.7	1.2e-08	0.77	0.04	0.96	FALSE
20	METSIM	Adipose	NCOA6	0.05	0.02	bslmm	373	0.02	1.3e-04	5.6	7.2	4.5e-13	0.88	0.06	0.94	FALSE
21	METSIM	Adipose	TP53INP2	0.05	0.03	lasso	3	0.04	1.3e-06	6.8	-6.9	7.1e-12	-0.97	0.03	0.97	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	NCOA6	0.07	0.08	blup	365	0.09	1.9e-11	-3.1	6.1	8.9e-10	0.68	0.80	0.20	FALSE
23	YFS	Blood	NCOA6	0.03	0.03	blup	368	0.03	6.9e-10	-3.2	6.1	1.3e-09	0.74	0.64	0.36	FALSE
24	YFS	Blood	TP53INP2	0.02	0.02	lasso	15	0.01	1.3e-05	6.8	-6.9	4.4e-12	-0.93	0.03	0.97	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NCOA6	0.05	0.02	blup	66	0.03	1.4e-03	6.8	6.5	6.7e-11	0.82	0.01	0.74	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	NCOA6	0.02	0.01	blup	66	0.02	1.5e-04	-2.1	5.6	2.5e-08	0.72	0.06	0.75	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	NCOA6	0.06	0.03	lasso	1	0.02	2.0e-02	6.8	6.8	1.1e-11	0.91	0.01	0.83	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NCOA6	0.04	0.04	blup	65	0.03	1.3e-04	-3.1	5.3	1.4e-07	0.65	0.27	0.52	FALSE
29	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NCOA6	0.15	0.06	blup	65	0.06	1.9e-04	-3.1	5.9	3.3e-09	0.69	0.08	0.55	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCOA6	0.04	0.02	blup	65	0.04	6.1e-05	6.8	6.6	5.6e-11	0.87	0.02	0.95	FALSE
31	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NCOA6	0.29	0.05	blup	65	0.05	7.1e-03	-1.6	5.2	2.6e-07	0.66	0.05	0.25	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	MAP1LC3A	0.04	0.00	blup	45	0.01	1.5e-02	6.8	6.1	8.1e-10	0.89	0.01	0.66	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	NCOA6	0.03	0.01	blup	65	0.02	5.2e-03	6.6	6.0	1.6e-09	0.78	0.02	0.51	FALSE
34	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NCOA6	0.14	0.00	blup	66	0.03	5.4e-02	4.9	6.3	2.6e-10	0.85	0.02	0.64	FALSE