Best TWAS P=5.18e-11 · Best GWAS P=1.35e-10 conditioned to 0.0157
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ASCC1 | 0.09 | 0.06 | lasso | 5 | 0.06 | 7.3e-08 | -5.1 | 5.3 | 9.2e-08 | -0.61 | 0.62 | 0.38 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | CHST3 | 0.12 | 0.12 | lasso | 6 | 0.11 | 1.1e-13 | 4.9 | 5.7 | 1.0e-08 | -0.75 | 0.62 | 0.38 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | SPOCK2 | 0.17 | 0.06 | lasso | 3 | 0.05 | 1.6e-03 | -5.1 | -5.2 | 2.0e-07 | 0.60 | 0.55 | 0.36 | FALSE |
| 4 | GTEx | Adrenal Gland | SPOCK2 | 0.44 | 0.46 | lasso | 15 | 0.46 | 3.5e-18 | -5.0 | 5.4 | 6.0e-08 | -0.85 | 0.70 | 0.30 | FALSE |
| 5 | GTEx | Adrenal Gland | DNAJB12 | 0.18 | 0.06 | lasso | 5 | 0.10 | 2.2e-04 | 4.7 | 6.1 | 1.4e-09 | -0.53 | 0.39 | 0.32 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | SPOCK2 | 0.05 | 0.03 | enet | 5 | 0.00 | 4.7e-01 | -5.1 | -5.2 | 1.9e-07 | 0.62 | 0.05 | 0.22 | FALSE |
| 7 | GTEx | Esophagus Muscularis | ASCC1 | 0.16 | 0.03 | enet | 23 | 0.04 | 2.0e-03 | -5.3 | 5.1 | 3.0e-07 | -0.52 | 0.42 | 0.32 | FALSE |
| 8 | GTEx | Esophagus Muscularis | DNAJB12 | 0.07 | 0.07 | lasso | 3 | 0.06 | 2.6e-04 | 4.7 | 5.2 | 1.7e-07 | -0.40 | 0.44 | 0.20 | FALSE |
| 9 | GTEx | Heart Left Ventricle | SPOCK2 | 0.25 | 0.22 | enet | 11 | 0.26 | 3.7e-14 | -5.3 | -5.2 | 2.3e-07 | 0.60 | 0.43 | 0.56 | FALSE |
| 10 | GTEx | Muscle Skeletal | SPOCK2 | 0.08 | 0.03 | lasso | 3 | 0.05 | 2.5e-05 | -5.3 | -6.2 | 6.8e-10 | 0.72 | 0.04 | 0.96 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | ASCC1 | 0.23 | 0.12 | lasso | 7 | 0.11 | 3.7e-09 | -5.3 | 5.5 | 4.6e-08 | -0.47 | 0.48 | 0.52 | FALSE |
| 12 | METSIM | Adipose | ASCC1 | 0.11 | 0.05 | lasso | 9 | 0.05 | 2.4e-08 | -5.1 | 5.4 | 6.7e-08 | -0.50 | 0.70 | 0.29 | FALSE |
| 13 | METSIM | Adipose | SPOCK2 | 0.06 | 0.06 | lasso | 10 | 0.07 | 1.3e-10 | 5.4 | -6.0 | 1.6e-09 | 0.70 | 0.45 | 0.55 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | CHST3 | 0.15 | 0.18 | lasso | 5 | 0.18 | 1.1e-22 | 5.6 | 5.5 | 4.9e-08 | -0.66 | 0.16 | 0.84 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SPOCK2 | 0.02 | 0.01 | blup | 66 | 0.01 | 7.8e-04 | -5.1 | -6.1 | 1.1e-09 | 0.77 | 0.36 | 0.34 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SPOCK2 | 0.11 | 0.08 | lasso | 7 | 0.09 | 3.9e-10 | -5.1 | -5.5 | 4.1e-08 | 0.73 | 0.56 | 0.44 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ASCC1 | 0.07 | 0.05 | blup | 73 | 0.09 | 1.1e-10 | 5.5 | 6.5 | 8.2e-11 | -0.71 | 0.02 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ASCC1 | 0.13 | 0.07 | lasso | 9 | 0.09 | 1.9e-04 | -5.3 | 5.6 | 2.2e-08 | -0.57 | 0.30 | 0.43 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ASCC1 | 0.08 | 0.05 | lasso | 4 | 0.06 | 1.7e-06 | -5.1 | 5.1 | 3.1e-07 | -0.58 | 0.63 | 0.36 | FALSE |
| 20 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SPOCK2 | 0.07 | 0.08 | enet | 11 | 0.07 | 5.4e-05 | 5.1 | -6.6 | 5.2e-11 | 0.72 | 0.11 | 0.76 | TRUE |