Best TWAS P=3.13e-10 · Best GWAS P=1.32e-08 conditioned to 0.786
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CEP170 | 0.05 | 0.02 | bslmm | 378 | 0.03 | 1.9e-04 | -2.9 | 6.3 | 3.1e-10 | -0.29 | 0.28 | 0.23 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SDCCAG8 | 0.13 | 0.10 | enet | 32 | 0.11 | 5.6e-13 | -4.6 | 5.4 | 6.9e-08 | -0.19 | 0.56 | 0.44 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | SDCCAG8 | 0.15 | 0.04 | enet | 13 | 0.09 | 2.8e-05 | -3.3 | -5.1 | 3.1e-07 | 0.16 | 0.52 | 0.30 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | SDCCAG8 | 0.17 | 0.07 | enet | 15 | 0.06 | 5.5e-03 | -3.5 | -5.5 | 3.4e-08 | 0.03 | 0.14 | 0.11 | FALSE |
| 5 | GTEx | Muscle Skeletal | SDCCAG8 | 0.05 | 0.01 | lasso | 3 | 0.02 | 3.5e-03 | -4.0 | -5.6 | 2.5e-08 | 0.13 | 0.09 | 0.14 | FALSE |
| 6 | NTR | Blood | SDCCAG8 | 0.03 | 0.01 | blup | 356 | 0.01 | 1.4e-04 | -3.3 | -6.2 | 5.2e-10 | 0.49 | 0.90 | 0.06 | TRUE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | AKT3 | 0.02 | 0.00 | blup | 155 | 0.00 | 3.2e-01 | -4.8 | -5.5 | 4.0e-08 | 0.54 | 0.06 | 0.50 | TRUE |