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chr3:140,350,567-143,224,385

Best TWAS P=1.6e-64 · Best GWAS P=2.46e-63 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PLS1	0.10	0.08	lasso	12	0.09	2.7e-11	-13.2	13.0	8.9e-39	-0.01	0.09	0.91	FALSE
2	GTEx	Adipose Subcutaneous	ATR	0.06	0.03	enet	20	0.06	1.5e-05	-15.2	-14.5	1.1e-47	-0.03	0.06	0.94	FALSE
3	GTEx	Adipose Subcutaneous	ZBTB38	0.08	0.04	lasso	4	0.03	8.1e-04	16.8	17.0	1.6e-64	0.98	0.01	0.99	TRUE
4	GTEx	Adipose Subcutaneous	RP11-383G6.4	0.06	0.03	lasso	6	0.03	1.6e-03	11.0	-12.1	1.6e-33	-0.05	0.17	0.80	FALSE
5	GTEx	Artery Tibial	ATR	0.07	0.03	enet	9	0.03	1.2e-03	-8.8	-8.6	6.0e-18	-0.02	0.46	0.14	FALSE
6	GTEx	Artery Tibial	RP11-383G6.4	0.10	0.03	lasso	6	0.06	3.9e-05	10.6	-9.5	1.8e-21	-0.10	0.40	0.58	FALSE
7	GTEx	Brain Cerebellar Hemisphere	XRN1	0.10	-0.01	lasso	4	-0.01	5.8e-01	-12.9	-12.7	9.1e-37	0.02	0.06	0.51	FALSE
8	GTEx	Brain Cerebellar Hemisphere	ATR	0.10	0.06	lasso	4	0.03	4.5e-02	-11.2	-11.4	4.1e-30	0.02	0.04	0.77	FALSE
9	GTEx	Brain Cerebellar Hemisphere	RP11-383G6.4	0.11	0.13	lasso	2	0.13	3.6e-04	-13.0	-13.0	2.2e-38	0.03	0.04	0.87	FALSE
10	GTEx	Brain Cerebellum	ATR	0.14	0.06	lasso	5	0.03	5.8e-02	-16.5	-16.0	8.5e-58	0.00	0.02	0.80	FALSE
11	GTEx	Brain Cerebellum	RP11-383G6.4	0.14	0.01	lasso	5	0.00	4.3e-01	-16.5	-15.3	6.4e-53	-0.02	0.02	0.86	FALSE
12	GTEx	Cells Transformed fibroblasts	GK5	0.18	0.09	lasso	8	0.09	1.4e-07	-6.7	-5.4	7.5e-08	0.06	0.98	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	RP11-383G6.4	0.07	0.05	lasso	4	0.06	2.8e-05	12.3	-14.8	2.8e-49	0.01	0.03	0.97	FALSE
14	GTEx	Esophagus Mucosa	XRN1	0.07	0.02	lasso	4	0.00	2.1e-01	11.0	-9.4	8.0e-21	-0.09	0.18	0.47	FALSE
15	GTEx	Esophagus Mucosa	ATR	0.07	0.04	lasso	5	0.04	1.7e-03	-13.2	-13.8	2.7e-43	0.01	0.22	0.61	FALSE
16	GTEx	Esophagus Mucosa	RP11-383G6.4	0.09	0.09	lasso	2	0.06	1.3e-04	11.0	-11.3	9.3e-30	-0.06	0.73	0.12	FALSE
17	GTEx	Heart Atrial Appendage	XRN1	0.15	0.05	lasso	6	0.13	2.3e-06	11.1	-10.6	2.0e-26	0.01	0.36	0.25	FALSE
18	GTEx	Lung	ATR	0.09	0.03	lasso	3	0.03	1.7e-03	-13.9	-13.7	6.3e-43	-0.08	0.04	0.94	FALSE
19	GTEx	Lung	RP11-383G6.4	0.04	0.07	lasso	2	0.06	1.4e-05	-13.0	-13.9	9.6e-44	0.01	0.03	0.96	FALSE
20	GTEx	Nerve Tibial	ATR	0.12	0.11	lasso	6	0.12	1.4e-08	-16.5	-16.2	3.9e-59	-0.03	0.01	0.99	TRUE
21	GTEx	Nerve Tibial	RP11-383G6.4	0.07	0.04	enet	11	0.05	1.4e-04	-16.5	-15.8	2.8e-56	-0.03	0.01	0.99	FALSE
22	GTEx	Ovary	RP11-383G6.4	0.15	0.13	lasso	6	0.14	3.3e-04	-16.1	-15.2	7.5e-52	0.00	0.07	0.81	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	RP11-383G6.4	0.06	0.10	lasso	3	0.08	2.6e-05	-15.5	-15.5	4.4e-54	0.00	0.04	0.95	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TRPC1	0.09	0.04	lasso	2	0.04	4.8e-04	5.8	-5.7	1.5e-08	0.04	0.37	0.33	FALSE
25	GTEx	Stomach	RP11-383G6.4	0.07	0.05	lasso	2	0.02	3.6e-02	11.0	-11.3	1.1e-29	-0.08	0.08	0.54	FALSE
26	GTEx	Testis	ATR	0.15	0.13	enet	17	0.12	6.4e-06	-16.5	-15.8	4.1e-56	0.00	0.01	0.98	FALSE
27	GTEx	Testis	ZBTB38	0.14	0.06	lasso	8	0.05	2.8e-03	14.6	16.4	9.2e-61	0.60	0.23	0.63	TRUE
28	GTEx	Testis	RP11-383G6.4	0.14	0.06	enet	22	0.08	2.8e-04	-15.5	-10.9	7.1e-28	0.02	0.04	0.93	FALSE
29	GTEx	Thyroid	XRN1	0.07	0.06	lasso	4	0.09	1.6e-07	11.1	-11.5	1.4e-30	-0.08	0.20	0.80	FALSE
30	GTEx	Thyroid	ATR	0.06	0.03	lasso	4	0.03	2.8e-03	-16.1	-15.2	1.8e-52	-0.04	0.02	0.96	FALSE
31	GTEx	Thyroid	GK5	0.05	0.06	lasso	3	0.04	9.4e-04	-6.8	-6.8	9.3e-12	0.03	0.36	0.34	FALSE
32	GTEx	Thyroid	ZBTB38	0.11	0.03	enet	32	0.04	2.9e-04	14.7	13.8	5.1e-43	0.62	0.07	0.92	FALSE
33	GTEx	Thyroid	RP11-383G6.4	0.09	0.03	enet	20	0.06	1.3e-05	11.1	-13.2	1.6e-39	-0.04	0.05	0.95	FALSE
34	GTEx	Thyroid	RP11-485G4.2	0.13	0.09	enet	21	0.11	1.8e-08	-6.7	-8.7	2.5e-18	0.01	0.80	0.20	FALSE
35	METSIM	Adipose	GK5	0.02	0.00	bslmm	358	0.00	1.4e-01	-5.2	9.5	2.7e-21	0.05	0.07	0.31	FALSE
36	METSIM	Adipose	XRN1	0.03	0.03	lasso	3	0.02	9.6e-04	-13.0	-12.4	1.7e-35	0.03	0.47	0.23	FALSE
37	NTR	Blood	ZBTB38	0.03	0.01	lasso	3	0.01	2.2e-05	16.7	14.4	6.1e-47	0.87	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PLS1	0.08	0.04	lasso	6	0.03	7.2e-03	11.5	8.2	2.6e-16	0.06	0.12	0.07	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	GK5	0.08	0.01	enet	12	0.05	2.3e-06	-2.5	-7.0	3.2e-12	0.05	0.01	0.84	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZBTB38	0.04	0.03	lasso	3	0.04	3.0e-03	13.9	15.4	8.9e-54	0.60	0.04	0.38	FALSE