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chr15:50,152,948-51,750,846

Best TWAS P=1.55e-14 · Best GWAS P=1.28e-13 conditioned to 0.0361

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SPPL2A	0.10	0.05	blup	432	0.07	2.1e-09	5.5	-7.5	8.1e-14	-0.63	0.18	0.82	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TRPM7	0.06	0.03	bslmm	416	0.06	2.8e-08	-1.8	-5.6	2.0e-08	-0.41	0.91	0.05	FALSE
3	GTEx	Adipose Subcutaneous	SPPL2A	0.12	0.11	lasso	3	0.11	2.1e-09	7.4	-7.4	1.1e-13	-0.93	0.00	1.00	FALSE
4	GTEx	Artery Tibial	SPPL2A	0.12	0.05	enet	14	0.12	1.1e-09	-3.0	-5.7	1.6e-08	-0.60	0.20	0.80	FALSE
5	GTEx	Brain Cerebellar Hemisphere	SPPL2A	0.26	0.21	lasso	3	0.17	4.3e-05	5.4	-5.3	1.1e-07	-0.77	0.07	0.85	FALSE
6	GTEx	Breast Mammary Tissue (Female)	SPPL2A	0.07	0.00	lasso	2	-0.01	5.2e-01	7.4	-7.4	1.7e-13	-1.00	0.01	0.73	FALSE
7	GTEx	Cells Transformed fibroblasts	SPPL2A	0.28	0.11	enet	23	0.31	9.9e-24	7.4	-7.3	2.4e-13	-0.74	0.00	1.00	FALSE
8	GTEx	Colon Sigmoid	SPPL2A	0.14	0.03	enet	15	0.07	2.5e-03	4.8	-5.9	4.1e-09	-0.50	0.06	0.74	FALSE
9	GTEx	Esophagus Mucosa	SPPL2A	0.13	0.09	lasso	5	0.07	1.2e-05	7.4	-7.0	2.4e-12	-0.94	0.00	1.00	FALSE
10	GTEx	Lung	SPPL2A	0.08	0.08	lasso	4	0.07	6.0e-06	-5.3	-5.3	1.4e-07	-0.22	0.76	0.02	FALSE
11	GTEx	Muscle Skeletal	SPPL2A	0.09	0.04	lasso	5	0.06	1.4e-06	-2.9	-5.7	1.2e-08	-0.63	0.18	0.82	FALSE
12	GTEx	Pancreas	SPPL2A	0.10	0.11	lasso	2	0.08	3.4e-04	7.4	-7.4	1.1e-13	-0.99	0.00	0.97	FALSE
13	GTEx	Thyroid	SPPL2A	0.12	0.05	enet	15	0.11	1.3e-08	7.4	-7.5	6.7e-14	-0.78	0.00	1.00	FALSE
14	METSIM	Adipose	SPPL2A	0.11	0.03	blup	426	0.08	1.5e-12	5.4	-6.1	9.1e-10	-0.46	0.99	0.01	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP4E1	0.02	0.02	lasso	3	0.01	9.5e-04	-5.3	-5.5	3.6e-08	-0.20	0.07	0.88	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100132724	0.02	0.01	lasso	3	0.01	1.6e-03	-5.3	-6.1	1.2e-09	-0.32	0.04	0.76	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPPL2A	0.14	0.03	lasso	6	0.08	1.5e-16	-2.9	-5.8	8.8e-09	-0.54	0.97	0.03	FALSE
18	The Cancer Genome Atlas	Colon Adenocarcinoma	SPPL2A	0.12	0.05	blup	39	0.04	2.6e-03	-2.9	-6.3	2.4e-10	-0.59	0.03	0.31	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SPPL2A	0.19	0.12	blup	39	0.16	8.4e-18	-2.9	-6.4	1.4e-10	-0.65	0.98	0.02	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SPPL2A	0.21	0.04	blup	39	0.12	4.0e-07	7.0	-7.7	1.6e-14	-0.80	0.01	0.99	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPPL2A	0.17	0.07	lasso	3	0.15	1.3e-16	7.0	-6.5	5.7e-11	-0.76	0.01	0.99	FALSE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPPL2A	0.03	0.00	blup	39	0.01	1.3e-02	-2.9	-7.4	1.7e-13	-0.72	0.01	0.46	FALSE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPPL2A	0.32	0.07	enet	9	0.16	2.2e-16	-2.9	-6.6	3.4e-11	-0.63	0.25	0.75	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	SPPL2A	0.25	0.17	blup	39	0.24	7.3e-23	-2.9	-6.6	3.2e-11	-0.63	1.00	0.00	FALSE