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chr17:42,814,955-45,597,098

Best TWAS P=8.2e-11 · Best GWAS P=1.7e-08 conditioned to 0.126

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MAPT	0.05	0.09	blup	31	0.09	3.4e-11	-4.91	5.1	2.6e-07	0.35	0.01	0.98	FALSE
2	GTEx	Adipose Subcutaneous	ARL17A	0.58	0.25	lasso	5	0.37	1.3e-31	5.03	5.3	9.3e-08	0.89	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	CRHR1-IT1	0.50	0.74	enet	27	0.74	3.4e-89	-4.96	-5.3	1.3e-07	-0.31	0.01	0.98	FALSE
4	GTEx	Adipose Subcutaneous	KANSL1-AS1	0.39	0.67	enet	18	0.68	3.7e-75	-4.96	-5.2	1.6e-07	-0.31	0.01	0.98	FALSE
5	GTEx	Adipose Visceral Omentum	ARL17A	0.51	0.21	lasso	7	0.27	1.7e-14	5.64	5.5	3.7e-08	0.91	0.00	1.00	FALSE
6	GTEx	Adrenal Gland	ARL17B	0.40	-0.01	enet	20	0.17	9.5e-07	0.23	5.3	1.3e-07	0.61	0.01	0.64	FALSE
7	GTEx	Artery Aorta	MAPT	0.14	0.08	enet	17	0.09	1.0e-05	-4.94	5.8	8.4e-09	0.34	0.01	0.96	FALSE
8	GTEx	Artery Aorta	NSFP1	0.40	0.19	lasso	5	0.24	3.3e-13	5.64	5.4	8.8e-08	0.90	0.00	1.00	FALSE
9	GTEx	Artery Coronary	ARL17A	0.39	0.19	lasso	5	0.20	3.0e-07	5.64	5.6	2.4e-08	0.94	0.00	1.00	FALSE
10	GTEx	Artery Tibial	ARL17A	0.69	0.37	lasso	9	0.44	5.4e-38	5.64	5.4	5.4e-08	0.92	0.00	1.00	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ARL17A	0.69	0.23	lasso	14	0.28	8.3e-08	5.64	5.3	1.4e-07	0.90	0.00	1.00	FALSE
12	GTEx	Brain Cerebellum	ARL17A	0.69	0.35	lasso	13	0.44	2.1e-14	5.64	5.9	3.4e-09	0.95	0.00	1.00	FALSE
13	GTEx	Brain Hippocampus	CRHR1-IT1	0.20	0.25	enet	15	0.24	1.9e-06	-4.91	-5.2	2.1e-07	-0.30	0.01	0.97	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	ARL17B	0.28	0.17	enet	9	0.19	7.1e-06	5.64	5.4	7.8e-08	0.81	0.00	0.93	FALSE
15	GTEx	Breast Mammary Tissue	ARL17A	0.63	0.24	lasso	7	0.34	4.2e-18	5.03	5.9	4.7e-09	0.87	0.01	0.99	FALSE
16	GTEx	Breast Mammary Tissue	NSFP1	0.52	0.26	lasso	6	0.30	1.0e-15	5.03	5.3	1.3e-07	0.86	0.02	0.98	FALSE
17	GTEx	Breast Mammary Tissue (Male)	NSFP1	0.28	0.02	lasso	4	0.01	1.9e-01	5.03	5.5	4.0e-08	0.87	0.01	0.72	FALSE
18	GTEx	Breast Mammary Tissue (Female)	ARL17A	0.63	0.23	enet	17	0.32	3.2e-10	5.03	5.7	9.4e-09	0.79	0.01	0.99	FALSE
19	GTEx	Breast Mammary Tissue (Female)	ARL17B	0.11	-0.01	enet	18	0.03	4.0e-02	5.03	6.5	8.2e-11	0.70	0.02	0.52	TRUE
20	GTEx	Breast Mammary Tissue (Female)	NSFP1	0.54	0.21	lasso	5	0.26	1.6e-08	5.03	5.4	6.3e-08	0.89	0.01	0.99	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	NSF	0.20	0.07	lasso	2	0.10	3.4e-04	5.48	-6.1	1.4e-09	-0.70	0.01	0.93	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	KANSL1	0.50	0.14	lasso	5	0.30	2.4e-10	5.25	-5.8	6.2e-09	-0.64	0.01	0.98	FALSE
23	GTEx	Cells Transformed fibroblasts	KANSL1	0.24	0.06	lasso	4	0.13	1.1e-09	-4.13	-5.6	1.8e-08	-0.58	0.03	0.96	FALSE
24	GTEx	Colon Sigmoid	MAPT	0.12	0.18	enet	18	0.17	1.1e-06	-4.96	5.9	3.0e-09	0.39	0.01	0.98	FALSE
25	GTEx	Colon Transverse	ARL17A	0.64	0.14	lasso	4	0.22	5.2e-11	5.03	5.1	2.9e-07	0.79	0.01	0.99	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	ARL17A	0.53	0.26	enet	9	0.37	2.0e-14	5.03	5.2	1.7e-07	0.89	0.00	1.00	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	KANSL1-AS1	0.42	0.62	lasso	6	0.62	4.4e-28	-4.94	-5.2	2.6e-07	-0.32	0.01	0.98	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	ARL17B	0.15	0.06	enet	20	0.12	3.0e-05	5.03	6.0	2.3e-09	0.64	0.03	0.90	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	NSFP1	0.46	0.24	lasso	4	0.30	3.2e-11	5.64	5.4	5.1e-08	0.95	0.00	1.00	FALSE
30	GTEx	Esophagus Mucosa	KANSL1	0.23	0.08	lasso	3	0.08	9.3e-06	5.25	-5.2	2.4e-07	-0.76	0.00	0.99	FALSE
31	GTEx	Esophagus Muscularis	NSF	0.17	0.00	enet	17	0.01	1.4e-01	5.48	5.3	1.3e-07	0.67	0.01	0.92	FALSE
32	GTEx	Esophagus Muscularis	ARL17A	0.57	0.32	lasso	4	0.40	4.1e-26	5.03	5.6	2.9e-08	0.93	0.00	1.00	FALSE
33	GTEx	Esophagus Muscularis	MAPT	0.04	0.02	lasso	5	0.01	5.1e-02	-4.94	5.5	3.1e-08	0.34	0.01	0.54	FALSE
34	GTEx	Heart Atrial Appendage	ARL17A	0.39	0.20	lasso	4	0.22	5.3e-10	5.64	5.6	1.6e-08	0.94	0.00	1.00	FALSE
35	GTEx	Heart Atrial Appendage	NSFP1	0.47	0.25	lasso	4	0.29	2.4e-13	5.64	5.6	1.9e-08	0.94	0.00	1.00	FALSE
36	GTEx	Heart Left Ventricle	ARL17A	0.30	0.15	enet	19	0.15	2.4e-08	5.64	5.3	1.1e-07	0.78	0.00	1.00	FALSE
37	GTEx	Liver	ARL17A	0.34	0.18	lasso	9	0.18	9.8e-06	5.64	5.7	9.7e-09	0.86	0.00	0.95	FALSE
38	GTEx	Liver	NSFP1	0.27	0.24	lasso	2	0.22	6.3e-07	5.64	5.7	1.4e-08	1.00	0.00	0.99	FALSE
39	GTEx	Muscle Skeletal	KANSL1	0.10	0.05	enet	9	0.04	1.7e-04	5.25	-5.2	1.6e-07	-0.65	0.00	0.98	FALSE
40	GTEx	Muscle Skeletal	KANSL1-AS1	0.36	0.64	enet	16	0.65	1.4e-83	-4.94	-5.2	1.9e-07	-0.32	0.01	0.98	FALSE
41	GTEx	Nerve Tibial	ARL17A	0.65	0.25	lasso	5	0.40	2.6e-30	5.64	5.2	1.7e-07	0.86	0.00	1.00	FALSE
42	GTEx	Nerve Tibial	KANSL1-AS1	0.36	0.60	enet	19	0.60	1.9e-52	-4.94	-5.2	1.8e-07	-0.33	0.01	0.98	FALSE
43	GTEx	Ovary	KANSL1	0.15	0.04	lasso	3	0.10	2.1e-03	5.25	-5.8	5.7e-09	-0.69	0.01	0.52	FALSE
44	GTEx	Ovary	ARL17A	0.42	0.15	enet	5	0.16	9.6e-05	5.64	6.1	8.2e-10	0.87	0.00	0.98	FALSE
45	GTEx	Pancreas	CRHR1-IT1	0.37	0.45	enet	22	0.44	3.5e-20	-4.89	-5.1	2.7e-07	-0.33	0.01	0.98	FALSE
46	GTEx	Pituitary	KANSL1	0.58	0.24	lasso	4	0.24	8.9e-07	5.25	-5.1	3.0e-07	-0.75	0.00	0.96	FALSE
47	GTEx	Pituitary	ARL17A	0.63	0.43	lasso	6	0.42	8.6e-12	5.64	5.7	1.5e-08	0.99	0.00	1.00	FALSE
48	GTEx	Pituitary	ARL17B	0.27	0.22	enet	6	0.21	4.7e-06	5.64	6.2	6.0e-10	0.87	0.00	0.96	FALSE
49	GTEx	Pituitary	NSFP1	0.52	0.36	lasso	5	0.36	5.6e-10	5.64	5.3	1.3e-07	0.96	0.00	1.00	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	LRRC37A2	0.32	0.31	lasso	4	0.35	4.8e-20	-4.21	-5.2	1.6e-07	-0.46	0.59	0.38	FALSE
51	GTEx	Skin Sun Exposed Lower leg	LRRC37A2	0.22	0.33	enet	20	0.35	2.3e-30	-4.13	-5.2	2.4e-07	-0.46	0.60	0.36	FALSE
52	GTEx	Spleen	CRHR1	0.29	0.36	enet	16	0.34	1.7e-09	-4.84	-5.2	2.0e-07	-0.33	0.01	0.98	FALSE
53	GTEx	Stomach	KANSL1-AS1	0.37	0.53	enet	14	0.53	1.1e-29	-4.83	-5.3	1.5e-07	-0.33	0.01	0.98	FALSE
54	GTEx	Stomach	LRRC37A4P	0.31	0.41	lasso	9	0.43	3.9e-22	-4.91	5.1	2.8e-07	0.32	0.01	0.98	FALSE
55	GTEx	Testis	WNT3	0.14	0.10	enet	10	0.14	9.9e-07	-4.04	-5.2	2.1e-07	-0.49	0.41	0.54	FALSE
56	GTEx	Testis	LRRC37A	0.71	0.46	enet	10	0.55	5.7e-29	5.64	5.4	7.0e-08	0.85	0.00	1.00	FALSE
57	GTEx	Testis	PLEKHM1	0.14	0.10	lasso	12	0.07	5.5e-04	-4.91	5.1	2.8e-07	0.30	0.01	0.95	FALSE
58	GTEx	Thyroid	ARL17A	0.48	0.19	lasso	7	0.24	2.2e-18	5.64	5.1	2.7e-07	0.84	0.00	1.00	FALSE
59	GTEx	Thyroid	CRHR1-IT1	0.37	0.53	enet	31	0.53	1.0e-47	-4.89	-5.1	2.7e-07	-0.30	0.01	0.98	FALSE
60	GTEx	Uterus	LRRC37A	0.39	0.44	lasso	16	0.44	3.2e-10	-4.83	-5.3	1.4e-07	-0.38	0.12	0.87	FALSE
61	GTEx	Uterus	CRHR1-IT1	0.54	0.66	enet	19	0.69	4.4e-19	-4.90	-5.1	2.7e-07	-0.31	0.01	0.98	FALSE
62	METSIM	Adipose	LRRC37A	0.56	0.25	lasso	5	0.32	5.5e-49	5.64	5.7	1.2e-08	0.92	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC37A2	0.28	0.39	lasso	6	0.43	6.6e-40	-4.13	-5.2	1.9e-07	-0.43	0.57	0.40	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC37A2	0.21	0.21	blup	48	0.21	3.0e-12	-4.13	-5.2	2.3e-07	-0.43	0.59	0.37	FALSE
65	The Cancer Genome Atlas	Esophageal Carcinoma	LRRC37A2	0.46	0.24	blup	47	0.29	1.1e-09	-4.13	-5.2	1.8e-07	-0.41	0.52	0.45	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LRRC37A2	0.33	0.35	lasso	4	0.41	7.2e-50	-4.25	-5.6	2.4e-08	-0.53	0.60	0.37	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LRRC37A	0.24	0.16	lasso	2	0.19	3.9e-21	-4.25	-5.6	2.6e-08	-0.51	0.60	0.36	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WNT3	0.04	0.03	blup	57	0.04	3.2e-05	-4.27	-5.5	3.1e-08	-0.31	0.36	0.37	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LRRC37A2	0.31	0.33	lasso	6	0.36	9.1e-18	-4.22	-5.3	1.4e-07	-0.49	0.59	0.38	FALSE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LRRC37A2	0.19	0.25	enet	8	0.28	2.0e-19	-4.13	-5.6	1.7e-08	-0.54	0.61	0.36	FALSE
71	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MAPT	0.09	0.04	blup	84	0.08	8.7e-06	-4.25	5.4	7.3e-08	0.51	0.33	0.63	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA1267	0.05	0.04	enet	5	0.06	1.5e-06	-4.13	-5.3	9.5e-08	-0.49	0.10	0.81	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC37A2	0.35	0.43	enet	18	0.46	5.3e-54	-4.24	-5.7	1.1e-08	-0.47	0.61	0.35	FALSE
74	The Cancer Genome Atlas	Rectum Adenocarcinoma	LRRC37A2	0.32	0.24	enet	8	0.33	1.4e-08	-4.22	-5.3	1.4e-07	-0.41	0.32	0.60	FALSE
75	The Cancer Genome Atlas	Soft Tissue Sarcoma	LRRC37A2	0.43	0.26	enet	22	0.37	3.8e-23	-4.33	-5.6	2.3e-08	-0.60	0.59	0.37	FALSE
76	The Cancer Genome Atlas	Skin Cutaneous Melanoma	LRRC37A2	0.37	0.27	enet	15	0.34	5.2e-10	-4.13	-5.7	9.9e-09	-0.50	0.43	0.48	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	LRRC37A2	0.27	0.27	lasso	6	0.30	2.8e-22	-4.20	-5.3	1.1e-07	-0.47	0.60	0.37	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LRRC37A2	0.40	0.14	lasso	6	0.21	4.4e-08	5.25	-6.1	1.0e-09	-0.71	0.01	0.98	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1267	0.09	0.03	lasso	3	0.01	7.5e-02	5.25	-5.3	1.0e-07	-0.75	0.00	0.81	FALSE
80	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LRRC37A2	0.34	0.21	blup	48	0.29	9.1e-09	-4.13	-5.5	4.6e-08	-0.55	0.58	0.36	FALSE