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chr2:99,468,341-101,731,705

Best TWAS P=2.39e-14 · Best GWAS P=1.52e-15 conditioned to 0.00722

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AFF3	0.31	0.24	enet	32	0.25	9.2e-31	5.9	6.6	3.0e-11	0.53	1.00	0.00	TRUE
2	GTEx	Adrenal Gland	CHST10	0.18	0.04	lasso	4	0.05	5.6e-03	7.1	-7.6	2.4e-14	-0.71	0.25	0.35	TRUE
3	GTEx	Artery Aorta	AFF3	0.14	0.06	lasso	5	0.07	1.2e-04	7.2	6.2	6.1e-10	0.66	0.37	0.58	FALSE
4	GTEx	Artery Tibial	AFF3	0.06	0.04	enet	6	0.04	4.3e-04	-5.5	6.1	9.4e-10	0.65	0.16	0.78	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	CHST10	0.25	0.15	lasso	4	0.12	9.1e-05	-7.4	7.2	4.7e-13	0.69	0.11	0.72	FALSE
6	GTEx	Heart Left Ventricle	CHST10	0.17	0.01	lasso	4	0.04	2.8e-03	6.8	-5.4	5.9e-08	-0.42	0.64	0.32	FALSE
7	GTEx	Muscle Skeletal	LONRF2	0.07	0.08	lasso	4	0.08	2.5e-08	7.1	7.1	1.0e-12	0.58	0.60	0.40	FALSE
8	GTEx	Skin Sun Exposed Lower leg	LONRF2	0.05	0.03	lasso	2	0.02	9.3e-03	-7.1	7.4	1.2e-13	0.60	0.28	0.22	FALSE
9	GTEx	Thyroid	CHST10	0.05	0.05	lasso	5	0.03	2.6e-03	7.0	7.5	4.7e-14	0.64	0.15	0.78	FALSE
10	METSIM	Adipose	LONRF2	0.04	0.01	bslmm	445	0.02	1.9e-03	6.7	5.3	1.1e-07	0.55	0.31	0.54	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	AFF3	0.31	0.24	enet	38	0.25	3.5e-32	6.1	6.0	2.7e-09	0.44	1.00	0.00	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LONRF2	0.06	0.04	blup	69	0.04	3.4e-05	-7.0	7.3	2.1e-13	0.72	0.24	0.76	FALSE
13	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LONRF2	0.05	0.08	lasso	2	0.08	2.9e-05	-7.3	7.3	2.9e-13	0.72	0.07	0.71	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	AFF3	0.03	0.01	blup	240	0.02	6.6e-03	5.2	5.4	7.7e-08	0.32	0.13	0.46	FALSE
15	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHST10	0.04	0.03	blup	73	0.02	1.5e-03	-7.0	6.0	2.3e-09	0.52	0.03	0.92	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	AFF3	0.06	0.00	blup	244	0.01	1.3e-02	-2.9	5.6	2.7e-08	0.48	0.09	0.10	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	CHST10	0.04	0.04	lasso	3	0.03	2.6e-04	6.9	6.9	4.3e-12	0.56	0.03	0.96	FALSE